Initial Posting: 12/19/2015    Last Update: 9/15/2019
Question: I take a number of supplements and I think they are making my acid reflux worse. Which supplements could be causing my stomach irritation, and what can I do about it?
Answer: You may want to avoid supplements like vitamin B-6 and cocoa, which can irritate the stomach or cause heartburn in some people. Arginine may potentially increase stomach acid levels and worsen esophageal reflux (heartburn). (Be aware that arginine may be sold as a single ingredient supplement, or as an ingredient in a sexual enhancement supplement.) If taken with heartburn medication such as omeprazole (Prilosec), St. John's wort can worsen reflux symptoms.
A number of other supplements can cause nausea or stomach upset. Vitamin C may cause an "acid stomach" in some people, but fortunately, there is a special form of vitamin C which may be helpful.