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CoQ10 and Ubiquinol Supplements Reviewed by


  • What does CoQ10 do?

    People often take CoQ10 to offset a decline in natural levels of CoQ10 that occurs with the use of statin (cholesterol-lowering) medication (although it remains uncertain if CoQq10 reduces side effects of statins). It may also benefit people with congestive heart failure. CoQ10 may modestly lower elevated cholesterol levels, reduce migraine, and improve energy levels, although the evidence for these latter uses remains preliminary or mixed (see What It Does). There is little evidence that CoQ10 lowers homocysteine levels.

    Most of the CoQ10 in supplements is naturally produced by fermentation. After being absorbed into the body, more than 90% of CoQ10 is converted to its active form, known as ubiquinol (CoQH2-10), which is also available as a supplement (such as QH from Kaneka) and appears to have greater bioavailability (i.e., it raises blood levels more) (see  What It Is). "Nano" formulations of CoQ10 claim to have better absorption are also available, though the evidence for this is not strong.
  • How to take CoQ10?

    CoQ10 and ubiquinol are typically taken at a dose of 50 to 300 mg per day, although higher doses have been used (see Dosage). Generally, CoQ10 and ubiquinol are best absorbed when taken with or shortly after a fatty meal, although water-soluble forms can be taken without fats (see Absorption and Bioavailability Enhancers). It's best to divide doses of 100 mg or more into several smaller doses, taken throughout the day.
  • What did CL's tests of CoQ10 show?

    In laboratory testing, all of the products were shown to provide their listed amounts of CoQ10 or ubiquinol, which is an improvement over the results of our previous review. Cost comparisons, based on a 100 mg dose, showed you could spend as little as 8 cents to over $6 for an equivalent amount of CoQ10, and from 34 cents to $1.18 for ubiquinol (See What CL Found).
  • Best CoQ10 supplement?

    Among 34 CL Approved products, CL selected four Top Picks for regular as well as bioavailability-enhanced CoQ10 and ubiquinol supplements, each providing high quality CoQ10 or ubiquinol at very good value.
  • CoQ10 safety and side effects:

    At typical doses, CoQ10 and ubiquinol appear to be generally safe, even when taken for several years. Gastrointestinal side effects may occur, but can be minimized by breaking up the dose throughout the day, although it may interfere with sleep if taken before bed. CoQ10 may interact with certain drugs, including blood thinners and diabetes medications (see  Concerns and Cautions).

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Alphabetical list of CoQ10 and ubiquinol supplements compared in this review

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ActiveQ Ubiquinol 50 mg

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Bluebonnet Ubiquinol 100 mg

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ChewQ 100 mg

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Doctor's Best High Absorption CoQ10 With BioPerine

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Dr. Mercola Liposomal CoQ10

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Dr. Sinatra Omega Q Plus Max

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Finest Nutrition CoQ-10

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Garden of Life RAW CoQ10 200 mg

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GNC CoQ-10 100 mg

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View Larger Image 7574_large_HealthyOrigins-Ubiquinol-CoQ10-2021.png

Healthy Origins Natural Ubiquinol

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Kirkland Signature [Costco] Maximum Potency CoQ10 300 mg

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Life Extension CoQ10 100 mg with PQQ

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View Larger Image 7578_large_MaryRuths-CoQ10-2021.png

Mary Ruth's CoQ10 Gummies - Raspberry

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Mito-Medica H2Q 200 mg

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Nano Food Wonder Heart Liposomal CoQ10 - Raspberry Flavor

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Natural Factors Ubiquinol Active CoQ10 100 mg

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Nature's Bounty CoQ-10 200 mg

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NOW Extra Strength Ubiquinol 200 mg

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Nutrifii Omega-Q

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Premier Research Labs CardioVen

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Pure Encapsulations CoQ10 60 mg

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Puritan's Pride Q-Sorb CoQ-10 200 mg

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QGel 200 Double Strength Coenzyme Q10 200 mg

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Qunol Mega CoQ10 Ubiquinol

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Qunol Ultra CoQ10

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Spring Valley CoQ10 200 mg

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The Vitamin Shoppe Triple Strength Ubiquinol CoQ-10

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USANA Coquinone 30

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VetriScience Coenzyme Q10 10 mg - For Dogs + Cats

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Vitafusion CoQ10 - Natural Peach Flavor

You must be a member to get the full test results along with's recommendations and quality ratings. You will get results for 15 CoQ10 and ubiquinol supplements selected by and 19 others that passed testing in its voluntary Quality Certification Program. In this comprehensive review, you'll discover:
  • Which CoQ10 and ubiquinol supplements failed testing and which passed
  • CL's Top Picks, representing the best CoQ10 and ubiquinol supplements at lowest cost
  • Which supplements have special ingredients which may increase their absorption (such as polysorbate 80) and/or bioavailability (such as black pepper extract) — and the pros and cons of these formulas
  • CoQ10 and ubiquinol dosing for treating specific conditions
  • How to take CoQ10 and ubiquinol to reduce side-effects and enhance absorption
  • CoQ10 side-effects, drug interactions, and cautions  

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Additional Information
Tested through CL's Quality Certification Program prior to, or after initial posting of this Product Review.