Initial Posting: 5/15/2014    Last Update: 12/12/2019
Answer: Supplements shown to help with seasonal allergy symptoms include butterbur, bromelain, nettle, spirulina and conjugated linoleic acid (CLA). You can learn about the evidence for these supplements, including clinical studies, dosage and more, in the Encyclopedia article about Allergies >>
Preliminary research suggests that some probiotics may also reduce allergy symptoms. When taken with a daily antihistamine, one particular strain of probiotic was found to improve ocular (but not nasal) allergy symptoms. See the Probiotics Review for more information >>
EpiCor, a branded ingredient produced from the fermentation of "whole food" by brewer's yeast, may reduce nasal congestion, but not other symptoms, when taken during allergy season.
Curcumin (from turmeric) may improve seasonal allergy symptoms such as sneezing, runny nose, and nasal congestion, and decrease levels of certain inflammatory mediators.
Pycnogenol, a branded pine bark extract, may be helpful for birch allergies if taken far enough in advance of allergy season.
Laboratory research suggests stinging nettle (Urtica dioica) extract may bind to histamine receptors and inhibit certain inflammatory processes associated with seasonal allergy symptoms (Roschek, Phytother Res 2009). There appears to be just one study of its effects in people with allergies, which found that 58% of those who took stinging nettle (reported it to be effective in relieving their symptoms, compared to 37% of those who took a placebo. However, two of the twenty-one people who took stinging nettle dropped out of the study after their symptoms worsened. Participants took 600 mg of freeze-dried stinging nettle leaf at the onset of allergy symptoms and 300 mg as needed for one week (averaging about 3 doses per day) (Mittman, Planta Med 1990).
Preliminary studies suggest quercetin may help to inhibit the release of histamine and antigen-specific antibodies (IgE) involved in allergic responses to seasonal allergens, and may help to reduce certain symptoms in people with an allergy to cedar pollen, but more research is needed to confirm there is a benefit.
Be aware that while echinacea may be helpful for colds and respiratory infections in some people, it is not typically recommended for allergy symptoms. In fact, people who are allergic to ragweed, daisies, sunflowers, and other flowers may be more likely to have an allergic reaction to echinacea.
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