uses JavaScript to provide the best possible experience for our content, but your browser has it disabled. Learn how to enable it here.


Side Effects of Curcumin and Turmeric


Turmeric/curcumin supplements are generally safe, but gastrointestinal side effects may occur with higher doses and they can cause problems for people with gallbladder disease or kidney stones. They can also interact with medications, such as those for blood-thinning, blood-sugar-lowering, and immunosuppression, as well as the anti-cancer drug tamoxifen. Curcumin may also inhibit iron absorption. Be aware that black pepper extract (piperine) often added to curcumin to increase bioavailability also interacts with a number of medications.

Although rare, elevated liver enzymes and liver injury have been reported with the use of turmeric/curcumin supplements.

For more details about dose, side effects, adverse effects and drug interactions with turmeric and curcumin, see the Concerns and Cautions section of Curcumin and Turmeric Supplements Review (The Review includes our tests and comparisons as well as Top Picks among curcumin and turmeric products).

Join today to unlock all member benefits including full access to all CL Answers and over 1,300 reviews.

Join Now

Join now at


Join the conversation

Reyna L.19342
April 8, 2020

I use turmeric root about one finger size in my smoothie every day also l put some ginger.What do you think about it. Thank You so much

December 15, 2019

Thank you for all the wonderful information that you provide! I’m one of the rare people who actually have an acute allergic reaction to turmeric... including hives/itchy skin, GI upset/acid stomach, nausea, racing heart, trouble breathing. Not fun at all. I have a sister who has the exact same allergy. I was so disappointed as it has so many benefits. I have to avoid it in foods as well.

January 31, 2018

I been taking Terry Naturally Curcumin 750 mg once a day for about 3 years and this past week when I donated blood they found my iron count was low. When they took it from my other hand I was just over the limit to give so they took my blood. This is the first time this happened. Curcumin?
January 31, 2018

Hi Daniel - Please see the information about curcumin and iron absorption in the "Concerns and Cautions" section of the Turmeric/Curcumin Supplements Review:

January 31, 2018

my wife is taking Tumeric +

she is farting a lot.

any comments?

February 1, 2018

Give her a dozen roses. They smell nice. : D

February 4, 2018

Love that answer! tee hee

February 4, 2018


December 15, 2019

Is she old?

January 31, 2018

Is there any connection between turmeric and peripheral neuropathy?
February 5, 2018

Hi Barry - There is some preliminary evidence from animal studies that it might be helpful for peripheral neuropathy and diabetic neuropathy (;; A study in people with peripheral neuropathy reported that curcumin reduced pain when given in addition to an anti-inflammatory medication ( -- however, this study, which was conducted by someone with a financial interest in the formula used, was not blinded and did not include a placebo, so it’s not possible to conclude whether curcumin was effective. We’re not aware of any research suggesting the use of turmeric or curcumin causes or worsens peripheral neuropathy.

January 31, 2018

I used the product Relief Factor for 5 weeks but I had a headache for the last 3 weeks. I thought it was an allergy headache until I searched on the PubMed website. Sure enough! Headaches are a side effect of turmeric.
February 5, 2018

Hi Carol - Thank you for sharing your experience with this. We've added information about this potential side effect in the "Concerns and Cautions" section of the Turmeric/Curcumin Supplements Review:

Join today to unlock all member benefits including full access to CL Answers

Join Now

Join now at