Our Members Asked:
What are the best supplements for depression and anxiety?
A wide variety of natural supplements have shown some benefit in reducing depression and/or anxiety. Certain vitamin and mineral deficiencies can also cause depression.
Sign in to learn more how the following relate to depression and anxiety: Fish oil, CBD oil, probiotics, prebiotics, curcumin (from turmeric), saffron, 5-HTP, St. John's wort, SAMe, DHEA, Rhodiola rosea, folic acid, L-theanine, ashwagandha, N-acetyl cysteine (NAC), melatonin, valerian, kava, palmitoylethanolamide (PEA), apple cider vinegar, B vitamins, vitamin D, magnesium, glucosamine, carnosine, beta-alanine, and collagen supplements.
Related Reviews (11)
Latest Research Updates (Clinical Updates)
Kava Interactions With Medications
A CL Member noted that kava (which some people take to treat anxiety) may interact with medications prescribed to treat anxiety. We have added information about this to our CL Answer about kava interactions with medications.
Also see our article about supplements to avoid when taking Valium or Xanax.
Related CL Answers (20)
What are the health effects of apigenin and is it safe?
Apigenin, a flavonoid compound, is promoted for sleep, depression, cancer, and other conditions. Find out if it works and if it's safe.
What are the health benefits of palmitoylethanolamide (PEA), and is it safe?
Palmitoylethanolamide (PEA) is commonly promoted for its anti-inflammatory and pain-relieving effects. Find out if it works.
Are L-carnosine supplements helpful and safe?
Learn about the potential health benefits of L-carnosine, as well as possible safety concerns, drug interactions and cost.
What is hesperidin, what is it used for and is it safe?
Learn about hesperidin, including whether its beneficial for heart health, problems with circulation, stroke, cognitive function, depression, cancer and other conditions, and find out if it is safe.
What is GABA (gamma-aminobutyric acid)? Is it beneficial for stress, anxiety, insomnia or other conditions, and is it safe?
Find out about GABA (gamma-aminobutyric acid), including if it's beneficial for insomnia, epilepsy, stress and anxiety, high blood pressure and building muscle, and learn if taking GABA supplements is safe.
Are light boxes effective for preventing and treating seasonal affective disorder (SAD), also known as "winter depression," or circadian rhythm disorders such as jet lag? Which light boxes are best?
Learn about the benefits and safety of light boxes (including who is most likely to benefit), how to use these devices, which commercially available products appear to meet the technical requirements, and who should not use light boxes.
What are the health benefits of holy basil extract?
Learn about the health benefits of holy basil leaf extract. See the clinical evidence for and against holy basil extract for lowering blood sugar in people with type 2 diabetes, reducing anxiety and stress, boosting the immune system, and reducing the pain and inflammation of arthritis. ConsumerLab.com's answer explains.
What are the side effects of ashwagandha supplements?
Learn about the safety and side effects of ashwagandha supplements, including headache, sleepiness, upset stomach, blood pressure and more. ConsumerLab.com's answer explains.
Does magnesium help with depression?
Find out if having low magnesium levels increases the risk of depression and if supplements such as magnesium citrate, magnesium chloride, can help for depression. Also, find out how to make sure you are getting adequate magnesium. ConsumerLab.com's answer explains.
Rhodiola and ashwagandha are both promoted to help with stress and anxiety. Is it safe to take them at the same time?
Find out if it is safe to take ashwagandha and rhodiola together. Both herbs are promoted to help with stress and anxiety, but may also lower blood pressure and have other side effects. ConsumerLab.com's answer explains.
Can melatonin supplements cause depression or make depression worse?
Find out if melatonin supplements can cause depression or make depression worse. ConsumerLab.com's answer explains.
Are lithium orotate supplements as effective and safe as prescription lithium for bipolar disease and depression?
Lithium orotate supplement info, including proper dosage, safety, and how lithium orotate supplements compare to prescription lithium for bipolar disease and depression.
I've heard that having low B-12 or B-6 can cause depression. Is that true?
Find out if vitamin B12 or B6 deficiency can cause depression and how they can affect antidepressants.
I take St. John's wort for depression. Your report notes that it can interact with other medications. Would taking it several hours apart from other meds avoid this interaction?
St. John's wort (Hypericum perforatum) can interact with other medications, but can this be avoided by spacing out the dosages?
A blood test showed my vitamin D level is low. How do I know how much vitamin D to take?
Find out how to increase vitamin D blood levels, including a good target range.
Are there any supplements I should avoid when taking Valium or Xanax?
Find out which supplements should be avoided when taking benzodiazepines like Valium, Xanax, and Ativan.
Is Rhodiola rosea effective for depression and does it have other uses? Will ConsumerLab.com be testing these supplements?
Learn more about Rhodiola rosea, it's impact on depression and anxiety, including evidence from clinical studies and safety.
I'm taking Lumiday, a supplement to improve mood. It seems to help me but is it safe?
Lumiday info including side effects, drug interactions and reviews. Lumiday is a supplement marketed to improve mood.
I've read about several different forms of SAMe. Is one form better than another?
Learn about the various types of SAMe (S-adenosyl-L-methionine) supplements, along with their benefits for hormones & cell membrane health.
I take fluoxetine (Prozac), a SSRI drug to treat depression. Are there supplements I should avoid, or be taking, due to this drug?
Learn about Prozac (fluoxetine) drug interactions along with other supplements and SSRIs.
Join over 90,000 Members
Find the best products with instant access to our latest tests & reviews of over 1,400 health products.
Save money by finding high-quality products at lower cost.
Stay safe with the latest clinical findings & warnings.
See answers from our experts.
Stay informed with our e-newsletter.