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Product Review

NAC (N-Acetyl Cysteine) Supplements Review

Choose the Best NAC Supplement and Save Money

NAC Review 2026

Clinical Update

12/04/2017

What NAC (N-Acetylcysteine)

NAC is both a supplement and a drug used to treat conditions ranging from flu and chronic bronchitis to compulsive behavior. A recent study evaluated its use in preventing kidney injury during angiography (imaging of blood vessels). Get the results and learn more in the "What It Does" section of the NAC (N-Acetylcysteine) Supplements Review >> Also see our top choices among NAC supplements.

Product Review

Echinacea Supplements Review

Many Echinacea Supplements Fail CL's Tests. Make Sure You Know What You're Getting!

Echinacea supplements reviewed by ConsumerLab.com

Product Review

Prostate Supplements Review (Saw Palmetto and Beta-Sitosterol)

Find the Best Prostate Supplement for Symptoms of BPH. See Which Prostate Supplement Passed or Failed CL's Tests of Quality.

CL Answer

Is it true that NAC can help clear nasal passages?

Find out if N-Acetyl Cysteine (NAC) can help with post nasal drip & general sinus congestion and about supplements that may reduce cold symptoms.

Ill Woman in Bed Blowing Nose

CL Answer

Mullein Tea: Possible Health Effects and Safety

Mullein tea is often promoted for relieving symptoms of lung conditions, including coughing, hoarseness, sore throat, and shortness of breath. Find out if there is evidence to support these uses, and learn about possible side effects of mullein.

a cup of mullein tea on a table next to mullein flowers and leaves

CL Answer

What is the difference between cysteine and cystine?

Find out the difference between cysteine and cystine amino acids, including where each is found and their functions.

Young Woman Taking Supplement

CL Answer

Do any supplements help prevent or treat a cold?

Are there supplements that can help prevent or treat cold symptoms? Learn more about zinc, probiotics, vitamin C and more.

Supplements for Colds: Zinc, Echinacea & More -- Couple with cold, sitting on couch blowing their noses

CL Answer

Are people with kidney disease at risk of getting too much potassium if they take a multivitamin? Which multivitamins are best for people with kidney disease?

Learn if people with kidney disease are at increased risk of getting too much potassium from multivitamins, find out which multivitamins do not contain potassium, and learn what other products should be avoided by people restricting potassium intake.

Multivitamins on pharmacy shelf

CL Answer

Will pregnenolone help slow down aging or reduce chronic pain?

Learn more about the steroid hormone pregnenolone, including its effects in the body and on aging and chronic pain.

Elderly couple yoga pose in sunshine

CL Answer

Do any supplements help with pancreatitis? Do any cause pancreatitis?

Find out if supplements including digestive enzymes, antioxidants, or medium-chain triglycerides are beneficial for chronic pancreatitis, and learn which supplements might worsen symptoms.

Person with pancreatitis holding their abdomen

News Release

April 15, 2026

Think Expensive NAC Is Better? ConsumerLab Tests Say Otherwise

White Plains, NY, April 15, 2026 — NAC (N-acetyl cysteine) supplements are widely marketed for “detoxification,” immune support, and respiratory health, as NAC is converted in the body into the antioxidant glutathione.

CL Answer

Can vitamins or other supplements cause a change in the ability to taste, or even a loss of taste?

Find out if supplements or vitamin deficiencies can cause changes in taste, loss of taste or smell. Information about vitamin D, zinc, vitamins A, B6, B12 and others. Plus medications and medical conditions that can alter taste and smell. ConsumerLab.com's answer explains.

Vitamin Deficiency, Supplements and Loss of Taste? -- man with salad looking disinterested, unhappy

CL Answer

Which supplements and foods help relieve constipation and which can cause constipation?

Find out which supplements can cause constipation, including iron, calcium, protein powders and drinks and others. ConsumerLab.com's answer explains.

Which supplements can cause constipation? -- Woman with gastrointestinal pain

CL Answer

Do any supplements help for varicose veins or chronic venous insufficiency?

Find out which supplements help for varicose veins and chronic venous insufficiency, including citrus bioflavonoids and grape seed extract.

Varicose Veins

CL Answer

Supplements For Back Pain: What Helps, What's Hype

Some supplements may provide modest benefit for back pain, while others don't seem to work or haven't been evaluated for this use. Find out if supplements like collagen, devil's claw, PEA, pregnenolone, white willow bark, and others help.

Man holding lower back due to low back pain

News Release

September 26, 2024

What’s Really In Shilajit Supplements? ConsumerLab Tests Reveal Amounts of Fulvic Acid & Heavy Metals

White Plains, NY, September 26, 2024 -- Shilajit is a tar-like substance created by decomposed plant material and found in mountain rocks.

News Release

March 11, 2019

Best NAC (N-acetyl cysteine) Supplements Identified by ConsumerLab

White Plains, New York, March 11, 2019 — NAC (N-acetyl cysteine) supplements are promoted for many uses, including "liver support," "immune support," and reducing symptoms of the flu and flare-ups of chronic bronchitis.

CL Answer

Are antioxidant supplements good or bad for you?

Learn more about whether antioxidants like astaxanthin, beta-carotene, coenzyme Q10, curcumin, resveratrol, selenium, vitamin A, vitamin C and vitamin E are safe and if they help prevent chronic diseases.

Can Antioxidants Cause You to Die Sooner? -- antioxidant supplements and carrots

Clinical Update

10/28/2024

Supplements for Varicose Veins

Do any supplements reduce the appearance of varicose veins or improve the symptoms of chronic venous insufficiency? Find out in our updated article about supplements for varicose veins and chronic venous insufficiency.

Clinical Update

1/11/2022

Ginkgo and Cistanche for Chronic Fatigue Syndrome?

Does supplementing with ginkgo and cistanche extracts help reduce symptoms of chronic fatigue syndrome? See what a recent study showed in our updated answer to the question: Which supplements help to improve energy and decrease fatigue?

Clinical Update

2/08/2020

Vitamin D for Hives

If you suffer from chronic hives (or chronic urticaria) and are deficient in vitamin D, taking vitamin D may be helpful, according to a new study. (Vitamin D may also be helpful for other skin conditions such as eczema and psoriasis.) Get the details in the What It Does section of the Vitamin D Supplements Review. Also see our Top Picks for vitamin D.

Clinical Update

9/18/2020

Vitamin D for Failing Hearts?

Does high-dose vitamin D help or hurt people with chronic heart failure? Find out what a new study showed in the Cardiovascular Disease section of Vitamin D Supplements Review, which also discusses cholesterol, blood pressure and heart attack risk. Also see our Top Picks for vitamin D.

Clinical Update

10/30/2021

Pycnogenol vs. Other Pine Bark Extracts

There is some evidence that pine bark extract may help improve circulation and chronic venous insufficiency, but be aware that some supplements are not like those used in most clinical trials. Find out what to look on labels in our updated answer to the question: What is Pycnogenol and does it work?

Clinical Update

11/11/2021

Multivitamins and Kidney Disease

People with chronic kidney disease are often advised to limit their intake of an ingredient that, they may not realize, is common in multivitamins. Learn more in the ConsumerTips section of the Multivitamin and Multimineral Supplements Review.

Clinical Update

10/24/2015

Probiotic Helps with Constipation

A recent study found that taking a particular probiotic twice a day after meals significantly increased the number of bowel movements in people with chronic constipation. For details about the probiotic and dose, see the Probiotic Supplements Review >>

Clinical Update

3/15/2017

Anti-Inflammatory Effect of Juice Plus+?

Chronic systemic inflammation is a risk factor for cardiovascular disease, diabetes, and cancer. A recent clinical trial assessed the product Juice Plus+ for its ability to reduce this inflammation in obese men and women. The abstract of the published study indicates that it works, but the results tell a different story. For details, see the "What It Does" section of the Greens and Whole Foods Powders, Pills, and Drinks Review (which includes our tests of products) >>

Clinical Update

12/03/2014

Vitamin D for COPD

A study of people with chronic obstructive pulmonary disease (COPD) found that taking vitamin D significantly reduced the risk of moderate to severe exacerbation, but only among people who began the study deficient in vitamin D. Get the details and information about other uses of vitamin D, along with our quality ratings of vitamin D supplements, in the Vitamin D Supplements Review >> 

Clinical Update

6/18/2019

Fish Oil for Heart Failure?

Can taking fish oil improve heart function in people with chronic heart failure? See the results of a recent study (and find out what type of fish oil was used) in the What It Does section of the Fish Oil Supplements Review. Also see our Top Picks for fish oils.

Clinical Update

12/05/2017

Fish Oil for Stress?

A recent study investigated whether taking fish oil rich in the omega-3 fatty acid EPA would reduce chronic stress. See the results in the "What It Does" section of the Fish Oil Supplements Review >>

Clinical Update

4/05/2016

Vitamin D Improves Heart Output

A recent study in people with chronic heart failure (poor heart output) found that vitamin D improved heart output. However, the study did not achieve its main objective — to increase walking distance. The dose may have been to blame. For details see the "What It Does" section of the Vitamin D Supplements Review >>

Clinical Update

11/16/2019

Supplement for Pain?

A recent study gave a modest daily dose of CBD to people with chronic pain who were taking opioid medication to see if it reduced their pain and need for medication. See the results in the What It Does section of the Review. Also see our Top Picks among products.

Clinical Update

2/21/2024

Lumbrokinase for Cancer, Infection?

Can lumbrokinase help slow cancer progression or treat chronic infections such as Lyme disease? Find out in our article about lumbrokinase.

Clinical Update

5/31/2024

Have Kidney Disease? Watch What’s In Your Water

People with chronic kidney disease are particularly susceptible to the toxic effects of heavy metals. Even low levels of lead in drinking water may be harmful, according to a recent study. See our Water Filter Pitchers Review for details. Also see our Top Picks among water filter pitchers.

Clinical Update

9/29/2023

Supplements for Pancreatitis?

Can digestive enzyme supplements work as well as prescription enzymes for chronic pancreatitis, and can any other supplements help? Find out, plus, learn if any supplements can cause pancreatitis, in our new article about supplements and pancreatitis.

Clinical Update

10/10/2023

Constipation & Supplements

Find out which supplements medical experts recommend for chronic versus occasional constipation. See the Laxative use section of our Psyllium Supplements Review, which includes our Top Pick among products.

Also see: Which supplements and foods help relieve constipation and which can cause constipation?

Clinical Update

11/07/2024

Vein Health: Does Butcher's Broom Help?

Does butcher’s broom reduce varicose veins or related symptoms? Find out in our updated article about supplements for varicose veins and chronic venous insufficiency (CVI).

Clinical Update

11/27/2024

B-12 Deficiency & GI Symptoms

Vitamin B-12 deficiency can cause many symptoms, including chronic diarrhea, as described in a recent report. Learn about symptoms of B-12 deficiency in our B Vitamin Supplements Review, which includes our Top Picks for B-12.

Clinical Update

10/28/2024

Triphala for Constipation?

Can Triphala, an Ayurvedic blend of fruits from three plants, help relieve chronic constipation and is it safe? Find out in our article: Which supplements and foods help relieve constipation and which can cause constipation?

Clinical Update

4/17/2025

Supplements for Varicose Veins?

Are any supplements recommended for varicose veins by vascular experts? Find out in our article about supplements for varicose veins or chronic venous insufficiency.

Clinical Update

4/24/2025

Microplastics Linked with High BP, Stroke

Exposure to higher amounts of microplastic was associated with increased risk of several chronic diseases, according to a recent study. Get the details in article about Microplastics in water, salt, foods, and beverages. Also see our Water Filter Pitchers Review for our Top Pick for removing microplastics.

Clinical Update

5/08/2025

Supplements for Hemorrhoids

Do supplements such as Pycnogenol, butcher’s broom, or aescin (found in horse chestnut), help people with hemorrhoids? Find out in our article: Do any supplements help for varicose veins or chronic venous insufficiency?

Clinical Update

10/16/2025

Constipation Solutions: What Works. What Doesn’t

Experts have weighed in on the best remedies for chronic constipation. Find out which foods and supplements made the cut:

Clinical Update

7/26/2022

Vitamin D and Heart Failure

Does high-dose vitamin D improve heart function in people with chronic heart failure? Find out what a recent study showed in the Cardiovascular disease, blood pressure, and cholesterol section of our Vitamin D Supplements Review.

Clinical Update

9/16/2022

Gluten & Dry Eye?

A CL member commented that their chronic dry eye went away after eliminating gluten from their diet. Is there clinical evidence that this can help? Find out in our article about supplements and lifestyle modifications for dry eye.

Clinical Update

12/06/2022

Digestive Enzymes – Prescription vs. Supplements

A CL member with chronic pancreatitis asked about alternatives to costly prescription enzymes. See our Digestive Enzyme Supplements Review for information about prescription enzymes as well as supplements similar to prescription products.

Clinical Update

12/09/2022

Allulose Questions

Clinical Update

2/10/2023

Magnesium and Artery Calcification

Did magnesium supplementation slow coronary artery calcification in people with chronic kidney disease? See what a recent study found in the What It Does section of our Magnesium Supplements Review, which includes our Top Picks for magnesium.

Also see: Which supplements or foods can help lower cholesterol and keep my heart healthy? Are there any to avoid?

Clinical Update

5/19/2023

Caution With Sweeteners

Certain sweeteners should not be used for decreasing weight or preventing chronic diseases, according to a new report. Find out which sweeteners are of concern and why in our updated article about sweeteners.

Clinical Update

5/31/2023

Best Fiber Supplement for Constipation?

Which type of fiber supplement is best for treating mild, chronic constipation? See what experts recommend, and why, in the What It Does section of our Psyllium Supplements Review.

Clinical Update

11/13/2025

Supplement for Spider Veins?

Does taking diosmin, a citrus bioflavonoid, reduce spider veins? Find out what a recent study showed in our article about supplements for chronic venous insufficiency.

Clinical Update

11/20/2025

Glucomannan for Constipation?

Did taking glucomannan (a prebiotic fiber) improve symptoms in people with chronic constipation? Find out what a recent study showed in our Prebiotic Supplements Review, which includes our Top Picks for prebiotics.

Clinical Update

4/06/2026

Krill Oil for Back, Hip, and Knee Pain?

Can krill oil ease chronic muscle and joint pain in older people? See what a new study found in our Fish Oil Supplements Review, which includes our Top Picks for fish oil and krill oil.

Recalls & Warnings

December 08, 2017

Limbrel Capsules for Osteoarthritis Linked With Potentially Life-Threatening Health Risk, FDA Warns

On December 4, 2017, the FDA urged consumers not to take Limbrel (Primus Pharmaceuticals), a capsule marketed to manage the metabolic processes associated with osteoarthritis, because it has been associated with serious adverse events, including drug-induced liver injury and a lung ...

News Release

December 09, 2014

Round-up of Recent Product Tests by ConsumerLab.com -- Results for B Vitamin Supplements & Energy Drinks, Garlic, NAC (N-acetyl cysteine), Iron and Omega-7 Fatty Acids

White Plains, New York, December 9, 2014 — In recent months, ConsumerLab.com has published test results for a variety of popular supplements, including B vitamins supplements and energy drinks, NAC (N-acetyl cysteine), iron and garlic. In addition, ConsumerLab.

Recalls & Warnings

March 31, 2005

FDA Warns Marketer of "Vitamin O" Product to Cease Unsubstantiated Claims

The U.S. Food and Drug Adminstration (FDA) has sent a Warning Letter (dated February 8, 2005) to Donald L. Smyth, President, R-Garden Inc., and Rose Creek Health Products, Inc. warning that its "Vitamin O" product was, among other things, being marketed with unsubstantiated health claims.

Recalls & Warnings

December 14, 2023

Pain Relief Tea Recalled, Found to Contain Prescription Drugs

On December 13, 2023, WS Global issued a recall of all lots of the company’s Himalayan Pain Relief Tea after products were found to contain diclofenac and dexamethasone, prescription drugs that are not listed on the product’s label.

Recalls & Warnings

October 21, 2014

Seller of Weight Loss, Saw Palmetto Supplements and More Warned for Drug Claims

On October 9, 2014, the FDA issued a warning letter to Bethel Nutritional Consulting, Inc., following a review of the company's website which found statements made about 15 Day Detox Diet, Alpha Lipoic Acid. 300 mg.

Recalls & Warnings

April 02, 2021

FDA Warns Sellers of Prostate, Reishi, Immune Products, and More

On March 16, 2021, the FDA issued warning letters to two companies following reviews of their websites which found statements made about the companies' products to be drug claims.

Recalls & Warnings

November 07, 2015

Seller of "NaturalDoctor" Vitamin C, Echinacea and More Warned for Manufacturing Violations

On October 16, 2015, the FDA issued a warning letter Sound Healing Arts, PC, dba Grounds for Tea, LLC, following a facility inspection which found the company's products, including  NaturalDoctor Vitamins C & K3, NaturalDoctor Goldenseal & Echinacea Plus, NaturalDoctor Centella ...

Recalls & Warnings

May 03, 2013

Maker of Omega-3, Saw Palmetto, St. John’s Wort Supplements And More Warned For Manufacturing Violations and Drug Claims

On March 19, 2013, the FDA issued a warning letter to Sunset Natural Products Inc.

Recalls & Warnings

December 17, 2020

FTC Crackdown on Six Deceptive CBD Products

On December 17, 2020, the FTC announced that it is taking action against six companies for selling CBD products with unsupported and deceptive health claims that they can treat a variety of conditions, including cancer, heart disease, hypertension, Alzheimer's disease, and others.

Recalls & Warnings

May 30, 2020

FTC Sends Refund Checks for TrueAloe and AloeCran

On May 26, 2020, the FTC announced it is mailing 22,581 checks totaling more than $470,000 to consumers who purchased deceptively marketed supplements, TrueAloe and AloeCran.

Recalls & Warnings

October 18, 2017

FDA Warns Seller of Arthritis, Blood Pressure, Diabetes Supplements For Making Drug Claims

On August 15, 2017, the FDA issued a warning letter to Years to Your Health, Inc., following an inspection of the company's website which found a number of their products to be misbranded, as they contained drug claims.

Recalls & Warnings

September 14, 2016

Seller of Aloe, Prostate and Joint Supplements Warned for Manufacturing Violations

On April 8, 2016, the FDA issued a warning letter to Salud Natural Entrepreneurs, Inc.

Recalls & Warnings

May 03, 2013

Homeopathic Company Warned For Drug Claims and Improper Labeling

On March 12, 2013, the FDA issued a warning letter to Natural Medicine Associates, Inc.

Recalls & Warnings

July 11, 2014

Maker of Cough and Sleep "Remedies" Warned for Drug Claims

On June 27, 2014, the FDA issued a warning letter to Zarbee's, Inc.

Recalls & Warnings

May 06, 2014

Seller of Flaxseed, Ginkgo and More Warned for Manufacturing Violations and Drug Claims

On April 18, 2014, the FDA issued a warning letter to Iowa Select Herbs, LLC, following a facility inspection which found the company's products, including Flax Seed, Holy Basil, Papaya Leaf Extract, and Ginkgo Leaf Extract products, to be adulterated because they were prepared, packed, or held ...

Recalls & Warnings

April 17, 2020

Seller of Vitamin D, MSM, Selenium & More Warned for Drug Claims

On March 31, 2020, the FDA issued a warning letter to KetoKerri LLC following a review of the company's website, which found statements made about some of the company's products, including Dr.

Recalls & Warnings

December 22, 2005

Health Canada Warns Consumers Not to Take Chaparral

On December 21, 2005, Health Canada (Canada's health ministry) warned consumers not to ingest the herb chaparral in the form of loose leaves, teas, capsules or bulk herbal products because of the risk of liver and kidney problems.

Recalls & Warnings

August 30, 2012

Supplement Company Warned For Medical Claims and Misbranding Of Omega-3, CoQ10, Noni Juice And More

On July 12, 2012, the FDA issued a warning letter to Alfa Vitamins Laboratories, Inc.

Recalls & Warnings

November 28, 2014

Seller of Herbal Extracts Warned for Manufacturing Violations, Drug Claims

On November 3, 2014, the FDA issued a warning letter to Avena Botanicals, Inc.

Recalls & Warnings

April 02, 2019

FDA Issues Strong Warnings to Sellers of CBD

On March 28, 2019, the FDA issued warning letters to three companies for making unsubstantiated claims about the health benefits of CBD (cannabidiol) products on their websites.

Recalls & Warnings

March 19, 2019

FDA Calls Promotion of Nyloxin Homeopathic Products for Pain a "Health Fraud Scam"

On March 11, 2019, the FDA issued a warning letter to Nutra Pharma Corp. following a review of the company's website (www.Nyloxin.com) and social media sites found that the company was making drug claims about its homeopathic products promoted for arthritis and cancer pain.

Recalls & Warnings

September 10, 2014

Seller of Joint Pain Supplement Warned for Drug Claims

On August 24, 2014, the FDA issued a warning letter to CreAgri, Inc., following a website review, which found statements made about the company's products, including Olivenol plus Easeflex, Olivenol plus Essence Capsules, and Olivenol plus Essence Elixer, to be drug claims.

Recalls & Warnings

September 13, 2013

Metagenics Warned For Misbranding of Medical Foods and Drug Claims

On August 13, 2013, the FDA issued a warning letter to Metagenics, Inc.

Recalls & Warnings

March 16, 2006

Garden of Life, Maker of Primal Defense, Settles FTC Charges

On March 9, 2006, The Federal Trade Commission (FTC) announced that an operation that marketed dietary supplements sold at Whole Foods Market, GNC, the Vitamin Shoppe, and on the Internet settled FTC charges that they made deceptive advertising claims about their supplements.

Recalls & Warnings

June 11, 2015

FDA Warns Maker of Fruit Energy Drinks for Drug Claims

On May 19, 2015, the FDA issued a warning letter to CK Management, Inc. following a facility inspection which found statements made on product labels and websites about Whole5, Fruit of the Spirit and ViaViente "whole food" fruit puree energy drinks to be drug claims.

Recalls & Warnings

July 15, 2014

Vita Springs Health Warned for Manufacturing Violations and Drug Claims

On June 24, 2014, the FDA issued a warning letter to Albert Max Inc.