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Question:
How should curcumin dose be adjusted if using formulations with enhanced bioavailability such as Meriva, BCM-95, CurcuWin, Theracurmin, Bioperine, and C3?

Answer:
If you're taking curcumin with just water (and not with foods containing fats or oils), these formulations can greatly increase the absorption and/or bioavailability of curcumin and other curcuminoid compounds, which will affect the dose you need to take. Find out more about each of these formulations and their suggested dosage in the "Absorption and Bioavailability" section of the Turmeric/Curcumin Review >>

Also see these related CL Answers:



Are supplements which claim increased absorption or improved bioavailability telling the truth? Is it worth paying more for these? Are there concerns? >>

I recently read that turmeric is only effective if it is combined with black pepper. Is this true? >>

Is Theracurmin better absorbed than other curcumin formulas - and can it really help lower my blood pressure? >>

Can turmeric or curcumin with black pepper extract cause constipation? I had this problem when taking a curcumin formula with piperine, but it resolved when I switched to a curcumin supplement without this added ingredient.  >>

How does turmeric spice compare to turmeric (curcumin) in supplements? I sprinkle it on my foods and wonder if that's equivalent to taking a supplement. >>

What is phytosomal curcumin? Does it have better absorption than other curcumin formulations? >>

 See other recent and popular questions >>
COMMENTS
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Hal14046   May 20, 2017
A recent article in forbes magazine references a study indicting there is no evidence in over 120 studies that Turmeric has any health benefits (https://www.forbes.com/sites/samlemonick/2017/01/19/everybody-needs-to-quit-it-with-this-turmeric-molecule/#79ff35fe79ff )
The study is at http://pubs.acs.org/doi/abs/10.1021/acs.jmedchem.6b00975 and concludes:
Curcumin is a constituent (up to ~5%) of the traditional medicine known as turmeric. Interest in the therapeutic use of turmeric and the relative ease of isolation of curcuminoids has led to their extensive investigation. Curcumin has recently been classified as both a PAINS (pan-assay interference compounds) and an IMPS (invalid metabolic panaceas) candidate. The likely false activity of curcumin in vitro and in vivo has resulted in >120 clinical trials of curcuminoids against several diseases. No double-blinded, placebo controlled clinical trial of curcumin has been successful. This manuscript reviews the essential medicinal chemistry of curcumin and provides evidence that curcumin is an unstable, reactive, nonbioavailable compound and, therefore, a highly improbable lead. On the basis of this in-depth evaluation, potential new directions for research on curcuminoids are discussed.
Thoughts on this, please.
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ConsumerLab.com   May 20, 2017
Hi Hal - We wrote about this study (Nelson, J Med Chem) when it came out earlier this year. It make some valid points but avoids discussion of formulations which overcome some of these issues. See the "What It Does" section of the Turmeric/Curcumin Supplements Review (https://www.consumerlab.com/reviews/turmeric-curcumin-supplements-spice-review/turmeric/#nelson) .
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This CL Answer initially posted on 10/9/2016. Last updated 7/26/2017.
ConsumerLab.com members may submit questions to CLAnswers@ConsumerLab.com. We read all questions and try to answer those of popular interest.
 
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