Answer:
As explained in our Reviews of each, vitamins
A,
D,
E and
K are fat-soluble and are better-absorbed when taken with a meal that contains fat. The same is true of
CoQ10,
curcumin (from turmeric),
CBD, and even
fish oil. If you must take these without a meal, there are
special formulations of CoQ10 and
curcumin that can improve their absorption by making them more water-soluble.
The key compound in
Boswellia serrata extracts (sold as a single-ingredient supplement or in combination with ingredients such as glucosamine and chondroitin in
supplements for joint health) is also fat-soluble and absorption may be enhanced by taking with fatty foods.
Certain other supplements are best taken with food because it can help to reduce potential side effects. For example, taking
magnesium with food can reduce the occurrence of diarrhea and taking
vitamin C,
iron or
SAMe with food can reduce the chance of stomach upset, although food is not needed for their absorption. (There are
vitamin C formulations and
iron formulations that may be less likely to cause stomach upset).
Although
protein supplements do not have to be taken with food, consuming protein drinks with a meal (rather than between meals) after resistance exercise may help to
increase muscle and reduce fat.
Preliminary evidence suggests that taking
green tea extract with a meal may reduce the chance of potential liver toxicity.
To find out whether a specific supplement is best taken with food, see the What to Consider When Using section in each product review >>
Mabel129
August 31, 2014The instructions on the SAM-e are to NOT take it with food. Not even within an hour of having eaten and preferable in the morning upon waking.
Hi Mabel - Food is not needed for absorption of SAMe, which may be why the label states to take without food; however, in clinical studies, people have been told they may take SAMe with food if it causes stomach upset.
Lida16399
January 31, 2018It is often impossible to take SAM-e on an empty stomach before a meal. Since I take a PPI that requires it to be taken 30minutes before breakfast, I cannot also take SAM-e as advised. I have reached out to NatureMade to get their opinion on the matter and they were not at all helpful. This is why I continue my membership with Consumer Lab.
Thank your for sharing your experience with this Lida, and we are glad to hear ConsumerLab has been helpful for you!