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Supplements for Osteoarthritis and Rheumatoid Arthritis -- Women With Arthritic Hands

Answer:

There are a number of supplements that may modestly reduce pain or improve other symptoms of osteoarthritis (inflammation caused by damage or "wearing away" of cartilage in joints) or rheumatoid arthritis (an autoimmune disease that causes joint pain, stiffness and inflammation).

Sign in as a member to learn more about supplements for osteoarthritis, rheumatoid arthritis, and other types of joint pain, including ashwagandha extract, avocado and soy unsaponifiables (ASUs), black seed oil, boswellia, cat's claw, cinnamon, coffee, collagen hydrolysate, curcumin, fiber, garlic, ginger, glucoraphanin and sulforaphane (compounds in broccoli), glucosamine and chondroitin, hyaluronic acid, krill oil, magnesium, modified citrus pectin (e.g., PectaSol-C), MSM, olive oil, omega-3 fatty acids, palmitoylethanolamide (PEA), potassium, propolis and bee pollen, rose hips, SAMe, selenium, tart cherry, vitamin B-5, vitamin D, vitamin E, and the products Wobenzym and Zyflamend.

Also see our tests and reviews of specific products in Product Reviews, including our Joint Health Supplements Review (covering glucosamine, chondroitin, MSM, and boswellia), Collagen Supplements Review (including UC-II and Vital 3), and Turmeric Supplements Review (including products such as Zyflamend).

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75 Comments

Stan22867
May 28, 2025

I have experimented with many of these recommended supplements for years with good results ( I’m 78, average weight, with some knee stiffness when climbing stairs - but with no need for any kind of pain medication). The only issue I've ever had is with a name brand of propolis. I found the odor of the capsule so strong, overpowering and unpleasant that I threw out the bottle.

Laurence22018
February 19, 2025

People:
I am 70 and was X-rayed with beginning arthritis in my one knee. The more I walked, the less it was noticed. I am in very fine health (take no medications) and I walk all over the place; plus, I do stretching exercises for a couple hours at a time. Nevertheless, I discovered I have this knee arthritis about 2 weeks ago. I kept up with my general diet/exercise routine BUT I increased and 'regularized' my taking of "Healthy Oils":
1. krill oil supplement 2. vitamin D supplement in soybean oil 3. eating of canned sardines and/or salmon 4. olive oil (organic in a bottle).
As I say, my ONLY change was in taking more and more regularly of some of the above "Healthy Oils" and keeping up with my stretching exercises and extensive walking all over town.
I can conclude: my pain is NEARLY non-existent. Even when in a stationary position--where the mild-to-moderate pain was at its worst--I can hardly notice its existence.

Laurence22072
February 25, 2025

Update: it appears the radiologist (or Physician Assistant) was in error: not sure where the error lies. It seems no arthritis was shown in the radiologist's report. My apologies for the above 'preliminary' report. However, for me, the above 'Healthy Oils' [for general health, too] and exercise properly performed has been key--squats is probably the best lower-body exercise I've done. You do not to be in fine form BUT the exercise needs to be properly performed.

Mark21971
February 13, 2025

I have shoulder and lower back osteoarthritis. Have tried Glucosamine, Boswellin with nominal effect at best. Started Palmitoylethanolamide (PEA) which had some effect on pain management and am still taking it. But after studying several clinical trials, identified proteolytic enzymes was shown to be as effect at pain management as diclofenac (like ibuprofen), but with much less adverse events, usually stomach upset or diarrhea. Have been taking Wobezym N (cheapest on Amazon) and it has taken all my pain away. It is a fairly rigorous treatment -- take three pills on an empty stomach (~1 hour before or after meal), three times a day. It has many benefits also in reducing fibrin, fibrosis, anti-inflammatory, and other benefits. But it has virtually stopped any OA pain. You need to titrate from two times a day for a week and then if tolerable, go to three times a day (9-12 pills a day for maximum effect). Read the ratings on Amazon for Wobezym N -- has 77% 5 rating -- very impressive. Lots of helpful testimonials for numerous types of arthritis, IBS, etc.

Marleina19500
May 14, 2024

I have severe OA in my thumb joints. I would love to hear what anyone takes that helps! Thx

Charlene19557
May 24, 2024

I have same issue, but both pinkies only. Weirdly, it's just the lowest joint next to fingertip.

Elizabeth19627
June 04, 2024

I have OA in my thumb joints and have found that adding a scoop of collagen peptides to my daily smoothies has significantly reduced my pain.

Holly19634
June 05, 2024

Charlene, I have that too. - I was told mine might be psoriatic arthritis. testing more next week.

Judi19907
July 02, 2024

Thumb joints OA greatly reduced by eliminating gluten and dairy from my diet. Thankfully for me, eggs are ok.
Delicious dairy alternatives are available!

Joann20892
October 15, 2024

Acupuncture helped me the most

Linda21192
November 25, 2024

Where was your pain located?

Allene21515
December 30, 2024

My hand joint pain was nearly eliminated when I quit eating nightshades. It seemed like over night.

Janette21520
December 31, 2024

I am currently experimenting with various supplements for osteoarthritis in the base of the thumb called carpometacarpal osteoarthritis, aggravated by an old injury. I already eliminate gluten and nightshade foods. Just wanted to add that a spica thumb splint has helped immensely. Currently wearing one I paid $6 for online.

Rick Meis21572
January 05, 2025

There are 2 non-pharm things that help(ed) the arthritis in my hands. Dark cherries really helped a lot, when in season. It was an acquaintance whose hubby owns a cherry orchard; all dark cherries. She noted they gave all the leftovers and culls to a neighbor during and after harvest; and his arthritis pain dropped way off. I started buying flats of cherries from them and, yup, it really helped. Now, with IBU, cherries and I don't get along.

Enter #2. Hyaluronic acid, Baxyl (Cogent Solutions). It really is noticeable. Early on, being a boy, when my hands felt better I would kind of quit. Then I noticed my hands hurt. I would start again. Repeat that countless times. Now, both my wife and I are good about taking it regularly, but living rurally, chores take a toll. So sometimes I put Votaren gel on my thumbs before bed.

Diane6704
October 09, 2023

I have Osteoarthritis in both knees and low back. I have been taking Glucosamine sulfate for a few years and it has really reduced my pain. I stopped taking it for a month or so this year and tea noticed the difference. This was on recommendation from my Naturopath. I still get occasional acute pain if I overdo some athletic activity, but by and large, it is working well for me. I do not have any financial interest in this or any supplement.

Mrs. John P.21529
January 02, 2025

Thanks for the information.

Elle
October 04, 2023

Collagen powder helped me with a shoulder injury from falling and some (but not all) friends with knee issues.

Shannon6697
August 25, 2023

For those of you who take Glucosamine, Chondroitin and or MSM for joint pain. How do you reduce the side effect of smelly flatulence? These supplements help my husband with joint pain but has this smelly side effect. If he goes off this 3-in-1 supplement the smelly gas goes away...Any suggestions

April6700
September 16, 2023

I take it every day without those side effects. I use 365 extra strength chondroitin glucosamine and msm from Whole Foods.

Janet6699
October 03, 2023

Some people may be more sensitive to sulphur, as in MSM, resulting in flatulence. I can't take it nor could my father.

Carl L6695
May 31, 2023

What about PEA for treating peripheral neuropathic pain?

ConsumerLab.com
June 22, 2023

Please see our article about palmitoylethanolamide (PEA): https://www.consumerlab.com/answers/palmitoylethanolamide-health-benefits-and-safety/pea/

joel6692
May 23, 2023

I took SAM-E for several years until a blood test revealed high liver enzymes that are associated with alchoholism (which I don't have). My doctor retested me 3 weeks after stopping the SAM-E, and everything was normal.

ConsumerLab.com
June 14, 2023

Thank you for sharing this. We are not aware of any published reports of SAMe causing elevated liver enzymes. Interestingly, it was thought that SAMe might be beneficial in people with non-alcoholic fatty liver disease (NALFD) based on laboratory research, but a preliminary study in people did not find a benefit (see our SAMe Supplements Review for details https://www.consumerlab.com/reviews/sam-e-review-comparisons/same/#nafld ).

Michael6689
May 23, 2023

I have debilitating rheumatoid arthritis. The only thing that alleviates the pain is Berifen. The side affect is that it hurts my kidneys. Does anyone have another solution.

Rebecca6690
June 12, 2023

Hello Michael, I was diagnosed with RA after experiencing extreme pain and restricted mobility in several joints. I found a resource on Arthritis.org that has changed everything for me. I started following the diet and exercise advice given by chef Seamus Mullen in his book Real Food Heals. Within 2 months the pain started easing and I lost 20 lbs. For the past 5 years I have followed chef Mullen’s advice and have maintained a healthy weight and remained pain free. I do not have a personal or financial interest in Mr Mullen’s book.

Michael6691
August 25, 2023

Michael28478: What a coincidence, my name is Michael (Mike) and I am exactly like you. I take Berefin every 24 hours for pain relief. If I don't, I am so stiff that I cannot move. I am going to see a Kidney specialist next week. I have been taking Berefin for 3 years. I think my kidneys are shot. I have had doctors give me other pills but Berefin is the only one that works. I can tell if I'm late as my muscles start to ache and stiffen up. Please keep in touch if you have found anything else other than Berefin to help.

Kristin6682
June 05, 2022

Has anyone had experience with WOBENZYM?

Betsy6683
September 26, 2022

I used it for several months a few years ago for all over joint pain similar to what I imagine fibromyalgia might feel like. It helped a lot—so much that I got lazy about using it and eventually stopped. I definitely need to go back on it and hope to do that soon.

Mark22216
March 11, 2025

Have shoulder OA (rotator cuff) and various discs with arthritis. Started on a Wobenzym N therapy, dosed three times a day on empty stomach. Had very good results and my shoulder pain is gone and mobility is normal. Lower back is much better.

jennifer22747
May 09, 2025

I’ve taken wobenzym for 10 years and it made a HUGE diff in pain levels due to OA and fibro.
I went off if once to determine and wow! It makes a world of diff. I take 3 tabs first thing in morning on empty tummy.

Dianne6678
May 18, 2022

Can Tumeric/Curcumin lower blood platelets?

ConsumerLab.com
May 18, 2022

See the Concerns and Cautions section of our Turmeric and Curcumin Supplements and Spices Review for information about turmeric's effects on platelet activity https://www.consumerlab.com/reviews/turmeric-curcumin-supplements-spice-review/turmeric/#warfarin

Deborah6675
May 17, 2022

I take 1400 mg of flaxseed oil twice a day for osteoarthritis pain in my hands. It has worked well for me for many many years. (I do not have a financial interest in any supplement products.)

Michael6677
May 24, 2023

Hi Deb. I just read your post. Were you taking any other supplements or ibuprofen etc on a regular basis. Thanks, Mike

Marleina6676
September 07, 2023

Hi Deborah, I too have osteoarthritis in my hands. Has there been a downside to taking the flaxseed oil for many years? May I ask, did you take only a flaxseed supplement rather than a combo one that had other things in it?

Allene19196
April 03, 2024

The day after I quit eating any nightshades, my arthritic hands were so much better. No potatoes, tomatoes, aubergines, etc.

Lynn6674
March 04, 2022

Has anyone tried Zyflamend to reduce inflammation and/or ease athritis symptoms?

Gale6671
May 09, 2021

Can persons with serious shell fish allergies safely take glucosamine and chondroitin? Are there any safe glucosamine/chondroitin supplements which do not contain shell fish?

ConsumerLab.com
May 20, 2021

Vegetable-based glucosamine in available as an ingredient in some products (see the "Concerns and Cautions" section of our Joint Health Supplements Review https://www.consumerlab.com/reviews/review-glucosamine-chondroitin-msm-boswellia-supplements/jointsupplements/#allergic). Also see the last column of the Results table in the Review, which notes products that are labeled as "Shellfish free" ( https://www.consumerlab.com/reviews/review-glucosamine-chondroitin-msm-boswellia-supplements/jointsupplements/#results).

anne6663
February 09, 2021

has anyone had success using SAME for knee arthritis

ellen6665
February 24, 2021

I have the same question about SAME, and also for Curcumin. My arthritis is in hands/wrists.

Glenn6664
May 05, 2021

Hello. I tried SAME for 3-4 months for my osteoarthritis pain in my hands, thumbs and toes and it didn't work.

Frieda
May 17, 2022

It seems to be working for me for arthritis in my hands. Very grateful!

Darren6667
May 18, 2022

I have had good results helping with the condition of two arthritic knees. Torn Acl in left knee, meniscus damage in right knee. I have had surgery on the right knee. Wear a sleeve on left knee to run and play tennis. Nature made SAM e has helped me. 800-1600 mg dosage per day

nancy6666
January 31, 2023

I had excellent results with Sam-e initially but then my arthritis worsened as it spread throughout my body. I was later diagnosed with rheumatoid arthritis. I then implemented a gluten-free and lectin-free diet (Plant Paradox diet). I am now pain free.

Lynn19905
July 02, 2024

I used to get cortisone shots in both knees due to osteoarthritis. Since I have been taking Glucosamine sulfate 1500 mg and Chondroitin sulfate 1200 mg per day divided into a third dose at each meal, my knees no longer hurt. No more shots!

ConsumerLab.com
August 12, 2024

See the "What It Does" section of our Joint Health Supplements Review for the evidence for and against glucosamine and chondroitin for joint pain https://www.consumerlab.com/reviews/review-glucosamine-chondroitin-msm-boswellia-supplements/jointsupplements/#whatitdoes.

Carol6661
September 19, 2018

I'm very pleased to see all these people have been helped by using one product or another, but... they don't say what type arthritis they have, so its irrelevant to the reader as to what might work for them.. PLEASE try to be more clear in describing what you're treating. Thanks.

eve6659
September 19, 2018

what about bromelain?

ConsumerLab.com
September 19, 2018

Hi Eve - As noted in the answer above, an enzyme supplement containing a combination of bromelain and other enzymes (Wobenzym) was found to be helpful for knee osteoarthritis. You can find more information about this in our Digestive Enzyme Supplements Review: https://www.consumerlab.com/reviews/digestive-enzyme-supplements/digestive-enzymes/#inflammation

Judy6658
September 19, 2018

Boswellia has done wonders for me! I rarely have knee pain anymore. I was getting injections in my knee periodically for the pain, but that's been over 3 years ago. I've taken Solaray Boswellia for at least 2-3 years. In addition, I ride a stationary bike for 30 minute 4-5 times a week which has also helped. I'm 67.

SUSAN6657
May 10, 2018

Black currant seed oil capsules have helped my arthritis, only 600mg a day but u can take much more!

Neville6653
March 18, 2018

Borax (boron) solved my arthritis problems. It may be difficult to source in the US. Pharmaceutical companies have done their best to ban it.

ConsumerLab.com
March 19, 2018

Hi Neville - Thank you for sharing your experience with this. There is some preliminary evidence that boron may be helpful for osteoarthritis. Please see this CL Answer https://www.consumerlab.com/answers/why-are-there-boron-nickel-and-tin-in-my-multivitamin/boron-nickel-tin/.

jeffrey6654
June 23, 2021

Boron has worked wonders for my osteoarthritis. I have no financial interest in the product.

Kathleen6641
October 18, 2017

What strength of curcumin is safe to take with "Doctors Best" high absorption with BioPerine. I am taking 1000mg and would like to take stronger

Arch6637
May 28, 2017

MSM has worked for me.
It provides sulfur and perhaps if your blood is insufficient in this, the MSM will work until cartridge's need for sulfur is satisfied.

Elizabeth6638
October 22, 2017

MSM has been helpful for my son and me for knee pain.

D4802
May 28, 2017

It's a shame that glucosamine/chondroitment tablets gets such bad press simply because a study found it doesn't help with knee arthritis. I and 4 other people I know swear by it for our shoulder and hand arthritis. I wish someone would do a more thorough study.

lynne6627
October 18, 2017

I agree it works well for myself and my husband!

Cameron6628
August 29, 2019

My father became wheelchair bound due to arthritis in his hips. Glucosamine/Chondroitin dramatically turned things around for him. The wheel chair ended up collecting dust in the garage.

Saundra6624
May 21, 2020

Glucosamine Sulfate works very well for me. I went off it for awhile just to see if it would make a difference. In a couple months I was right back to pain everywhere. When I take it, I don't feel pain anywhere. I'm talking pain as in couldn't shift my weight to one leg while standing because it hurt too much. Glucosamine is a life saver for me!

susan6634
July 02, 2022

It worked for me when i got sore knees running. After awhile I didn't need to take it anymore. I was much younger - 20s. I don't know if it would work now that i'm older.

peggy6611
May 12, 2017

I have been using magnesium oil to rub on my feet at night and it has helped with the pain of a severely arthritic foot. I have also noted that I no longer get cramps in my feet at night. I'm 78 so I think that I was not absorbing the Magnesium that I had been taking in a pill. As a side note, magnesium oil is actually not an oil but water combined with Magnesium which becomes oily. The only side effect is a slight tingling in the area which goes away. The combination of magnesium oil and Boswellia has allowed me to continue my daily walks with little pain.

kyehos
October 18, 2017

I have found the same type of benefit from direct application of magnesium oil onto the skin surface despite taking magnesium in capsule form.

Curtis W6617
December 20, 2020

About 15 years ago my knees were hurting and it was difficult to get up and down the basement stairs.. I started taking Cosamin DS which is glucosamine HCl worth can Chrondrotin. Not sure how long it took but I will soon able to go up and down the steps without pain and then I realize this stuff is working. I am now 81 years old and I have no joint pain other than my knuckle on my left hand index finger. I now take Body Dynamics joint renewal because it has several more ingredients in it like MSM, hyaluronic acid, I also think it’s critical to start early before you get bone on bone.
I can even keep up with my kids and grandkids at Disney World, and ride all the rides. That’s called a blessing.

Gale6615
September 07, 2021

I've taken Curcumin and Boswellia for many yrs. which lessens Celiac-and arthritic pain. And, as my inherited osteoarthritis in hands and feet worsened this past yr., I've found rubbing Magnesium Oil into hands and feet morning and at bedtime has amazedly reduced pain and joint swelling, --so much so that feet joints and badly deformed fingers on my right hand now appear nearly normal with little to no redness!
A year ago, an orthopedic physician told me "nothing will stop your joint degeneration, but thanks to Magnesium Oil --plus remedies described above, that's simply not true. I have a severe allergy to certain oral pain relievers which can often be more harmful than helpful.
Comfortable, well-fitting orthopedic shoes/sandals are a must, as is exercise, so we can stay strong and keep on enjoying life ConsumerLab reports are very helpful! Keep up the good work!!

ConsumerLab.com
September 09, 2021

Please see our Magnesium Review for more information about magnesium oil, creams and sprays https://www.consumerlab.com/reviews/magnesium-supplement-review/magnesium/#spray.

Gale6613
October 25, 2021

I'd like to add that this allergy season, when I, once again, began taking Stinging Nettle capsules for allergy relief, I found it also reduced my arthritis pain and swelling. Reading up, I found nettle is an old, trusted remedy ford both allergies and arthritis. Young nettles are easily found this time of year (to pick, wear gloves- it stings, however, cooking removes sting). It's good as a tea or cooked as a vegetable; however, it's easier to buy the inexpensive capsules for allergy and/or arthritis relief with no side effects.

peggy6606
January 11, 2017

I am so thankful for Boswellia which has reduced my joint pain significantly.

Victoria6608
May 28, 2017

Significant pain relief for me with boswelia

Carol6607
May 22, 2019

I have never seen Boswelia marketed by itself, only combined with other ingredients in a capsule. Please comment on what product you use. Thank you.

Carrie6609
June 23, 2021

I've tried Boswellia but found it gave me stomach pain.

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