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Clinical Updates
B Vitamin Supplements
Thiamin Alternative?
12/09/2022
Is thiamin tetrahydrofurfuryl disulfide (TTFD), a derivative of thiamin, absorbed and used by the body better than thiamin itself? Find out, and learn about possible health effects, in the Thiamin (B-1) section of our B Vitamin Supplements Review.
Nutritional Yeast for B Vitamins?
11/11/2022
Is nutritional yeast a good source of B-12 and other B vitamins? That depends on whether or not it is fortified. Get the details in the Getting B-12 from food section of our B Vitamin Supplements Review, which includes a list of foods containing B vitamins.
Symptoms of B-12 Deficiency
10/25/2022
Vitamin B-12 deficiency can cause a wide range of adverse effects affecting the nervous system, cognition, blood and blood pressure, and more. Learn about the symptoms and recent cases, and find out who is most likely to be deficient in our B Vitamin Supplements Review.
Also see our article: Top 8 Supplements for Vegetarians and Vegans.
Biotin for Skin Health?
10/07/2022
Biotin has been promoted for reducing wrinkles, but does clinical research support this? Find out in the Biotin (B-7) section of our B Vitamin Supplements Review, which also discusses the evidence for biotin for treating brittle nails and hair loss.
Also, see our CL Answer about supplements for reducing wrinkles and tightening the skin.
Nerve Pain & Vitamin B-6
10/04/2022
Vitamin B-6 deficiency can cause nerve pain and weakness, even resulting in inability to walk, as shown in a recent case. However, getting too much B-6 from supplements can also cause these symptoms. Find out how much B6 you should be getting in the Vitamin B-6 section of our B Vitamins Supplements Review.
For information about supplements that may help with other forms of nerve pain, see our answer to the question: Do any supplements, like Nervive, help with nerve pain, like sciatica or diabetic neuropathy?
Folic Acid & Risk of Self-Harm
9/30/2022
Can taking folic acid (vitamin B-9) reduce the risk of self-harm and suicide? Find out what a recent study found in the Depression section of our B Vitamin Supplements Review.
Don't Forget About Riboflavin
9/28/2022
A baby was recently born with severe riboflavin deficiency due to a lack of riboflavin in the mother's vegan diet and supplements. Learn more about riboflavin requirements in our B Vitamin Supplements Review.
B-12 and Insomnia?
8/09/2022
A CL Member had trouble sleeping when taking high dose B-12 to correct a deficiency and asked us if this is common. Find out in the B-12 section of our B Vitamin Supplements Review.
Metformin and B-12 Deficiency
8/02/2022
If you take metformin for diabetes, be aware that you are at risk for vitamin B-12 deficiency. See the latest guidelines to monitor for this in the B-12 section of our B Vitamin Supplements Review.
Increasing Folate from Beans & Peas
8/02/2022
Beans and peas are great dietary sources of folate (vitamin B-9), but the right preparation can more than double their folate levels, according to a recent study. Find out how in the Folate section of our B Vitamin Supplements Review.
Also see our table of Foods Containing B Vitamins to find out other foods that are good sources of folate and other B vitamins.
B-6 or B-12 for Anxiety?
7/26/2022
Can taking high-dose vitamin B-6 or B-12 improve self-reported anxiety? Find out what a recent study showed in the Anxiety section of our B Vitamin Supplements Review.
Also see our answer to the question: What are the best supplements for depression and anxiety?
B-6 or Zinc for Pyrrole Disorder?
7/22/2022
Can supplementing with vitamin B-6 or zinc improve psychiatric conditions associated with pyrrole disorder? Find out by using the links.
B Vitamins for Parkinson's?
7/15/2022
People with Parkinson's disease tend to have lower levels of vitamin B-6 and B-12. Find out if supplementing with B-6 or B-12 is beneficial and whether B-6 can interfere with drugs for Parkinson's.
B-5 for Arthritis?
7/08/2022
Can vitamin B-5 supplementation improve symptoms of rheumatoid arthritis or osteoarthritis? Find out what research suggests in the B-5 (Pantothenic Acid) section of our B Vitamins Supplements Review.
B-12 Deficiency & Stomach Surgery
6/28/2022
Many people who have had bariatric (stomach-reducing) surgery need to supplement with B-12 and other B vitamins. Find out what happened to such a person who discontinued supplementation in the Vitamin B-12 section of our B Vitamin Supplements Review.
Niacin & Shock-like Symptoms
5/03/2022
Taking very high doses of niacin can cause symptoms resembling anaphylactic shock, as was recently reported. Get the details in the Niacin section of our B Vitamin Supplements Review.
Severe B-12 Deficiency Can Be Missed
5/02/2022
B-12 deficiency can cause severe symptoms, even when B-12 levels in the blood are not low, as shown in a recent case. Find out why, and which tests can help, in the B-12 section of our B Vitamin Supplements Review.
MTHFR Mutations and B Vitamin Deficiencies
4/29/2022
People with a certain MTHFR gene mutation (C677T) may be more likely to develop B vitamin deficiencies. But what about those with a less common MTHFR mutation – A1298C? Find out what research suggests in the MTHFR gene mutation and B vitamin metabolism section of our B Vitamin Supplements Review.
B-12 for Nighttime Leg Cramps
4/26/2022
Raising lower blood levels of vitamin B-12 may help with nighttime leg cramps according to some reports. Get the details in the B-12 section of our B Vitamin Supplements Review.
For information about other supplements that may help, see our answer to the question: Do any supplements, foods, or oils help reduce muscle pain, muscle cramps, or nighttime leg cramps?
Vitamin B-12 Deficiency and Dementia
4/08/2022
Correcting B-12 deficiency may improve cognition in people with dementia, according to a recent study and case reports. Get the details in the Memory, Cognition, and Alzheimer’s Disease section of our B Vitamin Supplements Review.
B-12 Deficiency in Infants
3/25/2022
Although not common, B-12 deficiency can occur in infants. A recent study showed common symptoms and risk factors. Learn about B-12 deficiency in infants as well as in men and women in the B-12 section of our B Vitamin Supplements Review.
B-12 Deficiency and GI Symptoms
2/14/2022
Severe vitamin B-12 deficiency can cause a range of gastrointestinal symptoms, as highlighted in a recent case. Learn about these and other symptoms of B-12 deficiency in the B-12 section of our B Vitamin Supplements Review. Also see our Top Picks for vitamin B-12 and other B vitamin supplements.
B-12 Vitamin Deficiency and Darkening of the Skin
1/17/2022
Low levels of vitamin B-12 can cause darkening of the skin, as evidenced in a recent case. Get the details and learn about other symptoms of B-12 deficiency in our B Vitamin Supplements Review. Also, see our Top Picks among B-12 supplements.
Oral Symptoms of B-12 Deficiency
12/23/2021
Vitamin B-12 deficiency can cause a range of symptoms in the mouth, as described in a recent report. Learn about oral and other symptoms of B-12 deficiency in the B-12 section of our B Vitamin Supplements Review. Also, see our Top Picks for B-12 and other B vitamins.
High-dose Folate for Depression
11/14/2021
My psychiatrist told me to take high-dose of methylfolate to improve the effectiveness of my antidepressant. Is there evidence for this and is it safe? Find out in the Folate section of our B Vitamins Review.
Niagen for Energy?
10/08/2021
The maker of Niagen (a supplement containing nicotinamide riboside) was challenged regarding its claim that Niagen boosts energy and performance. See how the company responded in the Nicotinamide Riboside section of our B Vitamins Supplements Review.
Biotin Interference With COVID Tests
8/27/2021
Be aware that taking biotin (vitamin B-7) may interfere with COVID-19 antibody tests. Learn which tests are affected. Also find out about other laboratory tests (including thyroid and cardiovascular tests) that can be affected by biotin.
Danger With Too Much B-6
8/13/2021
A CL member recently told us about a friend who developed progressively worsening neuropathy (nerve damage) after taking very high dose vitamin B-6. It's important to be aware of the upper daily limit for vitamin B-6 and that taking too much can cause nerve damage, as well as skin lesions and other adverse effects, as discussed in detail in our B Vitamin Supplements Review.
Best Form of B-12 for Vegans?
8/09/2021
What form of vitamin B-12 appeared best at raising B-12 levels among people on plant-based diets in a new study, and how did this compare to getting B-12 from plant-based foods? Find out in the B-12 section of our B Vitamin Supplements Review. Also see our Top Picks for vitamin B-12.
Hidden Forms of B-12 Deficiency
7/12/2021
Vitamin B-12 deficiency can occur even in people with "normal" blood levels of B-12, as was most recently reported in a 30-year-old man. Learn more, including the wide range of symptoms of B-12 deficiency and information about testing for B-12 deficiency in our B Vitamin Supplements Review. Also see our Top Picks for B-12.
Niacin for Parkinson's?
7/09/2021
Can niacin supplementation improve symptoms or slow decline in people with Parkinson's disease? See what a new study found in the Niacin section of our B Vitamin Supplements Review.
Also see our answer to the question: Do supplements help with Parkinson's disease treatment or prevention?
Also see our answer to the question: Do supplements help with Parkinson's disease treatment or prevention?
Folic Acid for Hot Flashes?
5/17/2021
Can folic acid supplementation reduce hot flashes or improve mood in postmenopausal women? See what a new study found in the B Vitamin Supplements Review.
Folic Acid and Colorectal Cancer
3/22/2021
Do higher intakes of folic acid and other sources of folate increase or decrease the risk of colorectal cancer? It may depend on time, according to a new study discussed in the Folate section of our B Vitamin Supplements Review. Also see our Top Picks among B vitamin supplements.
Folic Acid for Cognitive Function?
2/27/2021
Does folic acid supplementation help with cognitive function in older people? Find out what a new study showed in the Memory and Cognition section of our B Vitamin Supplements Review. Also, see our Top Picks for folic acid.
Energy Drinks and Blood Pressure
2/09/2021
Which people are more likely to have cardiovascular side effects from energy drinks? Find out what a new study showed in the Energy Drinks & Shots section of our B Vitamins Supplements Review.
Thiamin Deficiency from Bowel Disease
2/02/2021
People with inflammatory bowel disease (such as Crohn’s or colitis) can develop thiamin (vitamin B-1) deficiency, which can lead to life-threatening brain injury, as noted in a recent review of 31 cases. Learn more about this and other causes of thiamin deficiency in the Thiamin section of our B Vitamin Supplements Review.
B12 for Diabetic Neuropathy?
1/30/2021
Can high-dose vitamin B12 improve nerve function and reduce pain in people with neuropathy due to type 2 diabetes? See what a new study found in the B12 section of the B Vitamin Supplements Review. Also see our Top Picks for vitamin B12.
Nicotinamide Riboside to Slow Aging and Reverse NAD+ Decline?
1/12/2021
Nicotinamide riboside, a form of niacin, has been promoted to slow aging, partially based on the belief that it raises NAD+ levels that fall with age. A new study raises doubts about this. Get the details in the Niacin section of our B Vitamin Supplement Review. Also, learn about a concern with taking too much nicotinamide riboside.
Magnesium, Niacin and Blood Pressure
1/09/2021
Two studies this week showed the risk of high blood pressure to be lowest among people with adequate, but not excessive, dietary intakes of magnesium and niacin.
Also, see which foods are good sources of magnesium and, separately, good sources of niacin.
B-12 for Eczema?
12/22/2020
Can vitamin B-12 deficiency worsen eczema and can supplementing with B12 help? Find out what happened in a recent case in the vitamin B-12 section of section of our B Vitamin Supplements Review. Also, see our Top Picks for vitamin B-12.
B-12 for Singers
11/17/2020
It is commonly believed that a shot of vitamin B-12 improves the performance of professional singers. A placebo-controlled study put this belief to the test. Get the results in the B-12 (cobalamin) section of our B Vitamin Supplements Review. Also see our Top Picks for B-12 and other B vitamins & complexes.
Biotin for MS?
11/10/2020
High-dose biotin was tried in people with multiple sclerosis (MS) to see if would reverse MS-related disability. Find out if it helped the Biotin section of the B Vitamin Supplements Review. Also, learn about concerns with high-dose biotin and see our Top Picks for biotin and other B vitamin supplements.
Muscle Cramps from Lack of Vitamin
11/03/2020
Painful muscle cramps in an older person resolved after correcting a deficiency in one of the B vitamins, according to a new report. Get the details, and learn which conditions and medications increase the risk of this deficiency, in the B Vitamin Supplements Review. Also see our Top Picks for B vitamin supplements.
Folate & Memory
8/31/2020
Older people with high blood levels of folate are more likely to perform worse on tests of memory and cognition unless they have sufficient levels of another B vitamin, according to a recent study. Get the details in the What It Does section of our B Vitamin Supplements Review. Also see our Top Picks among B vitamin supplements.
B-12 Supplements vs. Injections
8/24/2020
Can taking a B-12 supplement work as well as an injection to correct vitamin B-12 deficiency? See what a new study found in the B-12 section of the B Vitamin Supplements Review. Also see our Top Picks for vitamin B-12 and other B vitamin supplements.
B Vitamins and Fracture Risk
8/05/2020
High homocysteine levels have been linked with increased fracture risk in older people. Taking B vitamins can lower homocysteine levels, but does it lower fracture risk? Find out what a recent study using folic acid and B12 showed in the What It Does section of the B Vitamin Supplements Review. Also see our Top Picks for B vitamins.
High Blood Pressure Risk With Too Much Folic Acid During Pregnancy
5/14/2020
While it is important to take folate during pregnancy, a new study suggests that too much folic acid from supplements increases the risk of high blood pressure in mothers. See the details in the Folic Acid section of the B Vitamin Supplements Review.
Also see our Top Pick among prenatal vitamins, which provides adequate (but not too much) folic acid, in our Multivitamin and Multiminerals Supplements Review.
Also see our Top Pick among prenatal vitamins, which provides adequate (but not too much) folic acid, in our Multivitamin and Multiminerals Supplements Review.
Early Sign of Thiamin Deficiency
4/27/2020
Thiamin (vitamin B1) deficiency can cause lasting neurologic damage and affect heart function. It can occur with poor nutrition and as a result of taking certain diuretics. A recent case highlighted an early sign of thiamin deficiency that involves the eyes. We've added this information to the Thiamin section of the B Vitamin Supplements Review. Also see our Top Pick for thiamin and B complexes that contain thiamin. You can also get thiamin from a good multivitamin.
Biotin May Skew Many Blood Tests
2/28/2020
If you take a high-dose biotin supplement, be aware of the growing list of blood tests with which it may interfere. See the latest information in the Biotin section of the B Vitamin Supplements Review.
Cognitive Impairment From B12 Deficiency
2/24/2020
Vitamin B12 deficiency can cause a wide range of symptoms. This includes cognitive impairment, as shown in a recent case. For details about the symptoms of B12 deficiency see the B12 section of the B Vitamin Supplements Review. Also see our Top Picks for B12 and other B vitamin supplements.
Vitamin B12 and Risk of Death
2/10/2020
B12 & the Vegetarian
12/13/2019
Vegetarians and vegans are susceptible to vitamin B12 deficiency, which can be manifest by a range of health issues, including low blood pressure, as recently reported in an otherwise healthy young man. Learn more in the B12 section of the B Vitamin Supplements Review. Also see our Top Pick for vitamin B12.
B Vitamins for Cognition
11/28/2019
Increasing vitamin B-12 intake by those deficient in B-12 can help slow age-related declines in memory and cognition, but the dose needs to be sufficient, as suggested by a recent study. For details see the Memory, Cognition, and Alzheimer's Disease section of the B Vitamin Supplements Review. Also see our Top Picks for B-12 and other B Vitamins.
Platelet Concern With High-dose Niacin
11/10/2019
Long-term use of high-dose niacin may lower platelet counts. Learn more in the Niacin section of the B Vitamin Supplements Review.
Eye Risk With High-Dose Niacin
10/31/2019
Very high doses of niacin are sometimes used to lower high cholesterol, but there are risks -- including damage to the eye, as shown in a recent case. Get the details in the Niacin section of the B Vitamin Supplements Review.
Vitamin B12 & Sleepiness
9/20/2019
Vitamin B12 deficiency can cause a range of symptoms and, although rare, excessive daytime sleepiness is among them. Get the details about this, as well as information about other symptoms of B12 deficiency, in the B12 section of the B Vitamins Supplements Review. Also see our Top Pick for vitamin B12.
Folic Acid and Colon Cancer
8/12/2019
Several studies have evaluated whether folate from food and/or folic acid from supplements affect cancer risk. Find out what a recent report suggests about long-term, high-dose folic acid supplementation in the Folate section of the B Vitamin Supplements Review. Also see our Top Picks for folic acid and other B vitamin supplements.
Is Niagen Safe?
7/19/2019
Niagen (nicotinamide riboside) was recently studied for its safety and ability to raise NAD+ in the body. See the results and learn more about this form of niacin (which is also in the product Basis) in the Niacin section of the B Vitamin Supplements Review. Also see our Top Picks for niacin and other B vitamin supplements.
Is Methylfolate the Best Form of Folate?
7/15/2019
Methylfolate has been promoted as a better form of folate (vitamin B9), particularly for people with certain common genetic variations. A clinical study recently put methylfolate to the test against folic acid and folinic acid. The results were surprising. Get the details in the Folate section of the B Vitamin Supplements Review. Also see our Top Picks among folate and other B vitamin supplements.
NAD+ and Cancer?
6/18/2019
Supplements that raise NAD+ levels in the body have been promoted for anti-aging effects. But there is a theoretical risk that they could stimulate cancerous cells, and a CL member reported this week that a supplement containing such an ingredient, nicotinamide riboside, appeared to increase his PSA level. Learn more in the Niacin section of the B Vitamin Supplements Review.
Vitamin B12 & Depression
5/27/2019
Deficiencies in B vitamins, such as B12, can cause depression. A recent study suggests that, in pregnant women, even low-normal B12 levels are associated with a much higher risk of depression. For details, see the Depression section of the B Vitamin Supplements Review. Also see our Top Picks for B vitamins.
Hip Fracture Risk with B6
5/17/2019
Another study has shown a significantly increased risk of hip fracture with high intakes of vitamin B6 from supplements. For details, see the B-6 section of the B Vitamins Review. Also see how much B6 is in popular B vitamin supplements and our Top Picks.
Misdiagnosed B12 Deficiency
5/17/2019
Vitamin B12 is needed to make the genetic material in all cells. Consequently, B12 deficiency can cause a wide range of symptoms and may be misdiagnosed as other diseases. Read about two recent cases of misdiagnosed B12 deficiency in the Cobalamin (B12) section of the B Vitamin Supplements Review. Also see our Top Picks for B12.
Energy Drinks & Aggression
2/15/2019
Are people who frequently consume energy drinks (like 5-hour Energy) more likely to be aggressive or have mental health problems? Learn what a new study found, and learn more about the pros and cons of energy drinks in the Energy Drinks section of the B Vitamin Supplements Review.
B12 Tablet vs. Injection
1/14/2019
Is a vitamin B12 tablet just as good as an injection for raising blood levels of B12? Find out in the Cobalamin (B12) section of the B Vitamin Supplements Review. Also see our Top Pick for vitamin B12.
B Vitamins & Breast Cancer
1/07/2019
A reduced risk of breast cancer was associated with supplementing with certain amounts of folic acid and vitamin B12 for women predisposed to breast cancer in a new study. See the details in the "Breast cancer" section of the B Vitamin Supplements Review.
Liver Toxicity With Niacin
11/19/2018
B Vitamin Cancer Risk?
10/23/2018
Can a B Vitamin Lower High Blood Pressure?
10/08/2018
A common mutation of the MTHFR gene is associated with an increased risk of hypertension. A recent study tested whether supplementing with a specific B vitamin could reduce blood pressure in affected individuals. Get the results in the MTHFR section of the B Vitamin Supplements Review. (Also see our Top Picks among B vitamins.)
Niagen for Blood Sugar Control?
7/09/2018
Methylfolate vs. Folic Acid
6/11/2018
Methylfolate (L-5-methylfolate, sold as Metafolin and Quatrefolic) is a form of folate promoted for use by people with common genetic mutations that affect the MTHFR enzyme. But is it really better than folic acid? A study recently tested them head-to-head. Get the results in the Folate section of the B Vitamins Review. Also see our Top Picks among methylfolate and folic acid products.
Hair & Nail Supplements Can Skew Lab Tests
5/21/2018
There are reports of high-dose biotin (common in "hair and nail" supplements) causing false readings on blood tests. Be sure to tell your doctor if you're taking high-dose biotin. Get the details in the Biotin section of the B Vitamin Supplements Review.
Too Much Vitamin B6
5/14/2018
Be aware that you can get too much vitamin B6 from supplements and energy drinks. This can result in nerve damage and other adverse effects, as has been recently reported. For details, see the B6 section of the B Vitamin Supplements Review.
What Niagen Does
4/02/2018
Niagen (nicotinamide riboside) has been promoted as an anti-aging supplement. Find out what's been shown in clinical studies, including one published recently, in the Niacin section of the B Vitamin Supplements Review.
B12 Dosage
3/06/2018
A study compared the effects of a high weekly dose of vitamin B12 versus a much lower dose given daily. Both worked equally well. Find out why and get more details about B12 dosing in the B-12 section of B Vitamin Supplements Review.
Folic Acid, Multis & Autism Risk
2/24/2018
The use of a folic acid or multivitamin supplement during pregnancy was associated a reduced risk of autism spectrum disorder in children according to a recently published study. Be aware, however, that high-dose folic acid during pregnancy may have negative effects. For details, see the Folic Acid section of the B Vitamins Review.
B12 for Cognition
1/12/2018
Numerous studies show that getting adequate intake of B vitamins, such as B12, and, perhaps, omega-3 fatty acids from fish, may slow age-related declines in memory and cognition. But not everyone should expect a benefit, as shown in a recent study. For details, see the Memory, Cognition, and Alzheimer's Disease section of the B Vitamin Supplements Review. (Also see our Top Picks among products.)
Folic Acid & Risk of Autism
12/25/2017
Supplementing with adequate (and not excessive) folic acid around the time of conception is associated with a lower risk of autism in offspring, and a recent study suggests this may be particularly important for women who take antiepileptic medication. For details, see the "Folate" section of the B Vitamin Supplements Review >> (Also see information about getting folic acid from prenatal vitamins in the "Prenatal" section of the Multivitamin Review.)
Folic Acid for Cognition
12/22/2017
Giving folic acid to older people with relatively low levels of blood folate resulted in improved cognitive performance, according to a recent study. For details, see the "Memory, Cognition, and Alzheimer's Disease" section in the B Vitamin Supplements Review >> (Also see our Top Picks for folate and other B vitamin supplements.)
Danger from Too Much Vitamin B6
12/13/2017
A women who was consuming large amounts of an energy drink as well as a B-vitamin complex developed symptoms of vitamin B6 (pyridoxine) toxicity (which may not be reversible), according to a recent report. Get the details in the "B6" section of B Vitamin Supplements Review >>
CL has long warned that energy drinks and shots often contain large amounts of B6 and other B vitamins.
CL has long warned that energy drinks and shots often contain large amounts of B6 and other B vitamins.
Biotin Interference With Vitamin D Test
12/04/2017
Last week we reported that high doses of biotin (found in B complexes and hair and nail supplements) can interfere with certain blood tests. A study recently showed that biotin can also artificially inflate a test for vitamin D. Get the details in the "Biotin" section of the B Vitamin Supplements Review >>
Growing Concern with Biotin Causing False Lab Results
11/27/2017
Biotin (a B vitamin found in B-complex and hair and nail supplements) can interfere with laboratory results resulting in the missed diagnosis or misdiagnosis of cardiovascular and hormonal conditions, such as Graves' disease (a form of hyperthyroidism). Physicians and lab personnel may be unaware of this interference. For details, see the "Biotin" section of the B Vitamins Review >>
Signs of B12 Deficiency
11/25/2017
B12 deficiency is not uncommon, most often affecting older people. Symptoms include anemia, fatigue, tingling in the arms and legs and loss of balance -- but a recent case report highlights a lesser-known sign of B12 deficiency. Find out more, plus how much B12 you should get in the "B12" section of the B Vitamins Review >> (Also see our Top Picks for vitamin B12 and other B vitamins.)
B Vitamins for Memory
11/03/2017
Many studies suggest that adequate intake of B vitamins slows age-related declines in memory and cognition. This was recently shown again in a study in England. Find out which B vitamins help, and how much you need, in the "What It Does" section of the B Vitamin Supplements Review >> [Also see our Top Picks for B vitamin supplements in the Review.]
Best form of B12?
10/28/2017
It's important for many older adults and people using medications that reduce stomach acid to take a vitamin B12 supplement. Three different forms of B12 are sold. A recent study suggests that one may be better than another. Get the details in the B12 (cobalamin) section of the B Vitamin Supplements Review >> [Also see our Top Pick for B12 supplements in the Review.]
Niacinamide for Alzheimer's Disease?
9/18/2017
Niacinamide (a form of niacin) has been promoted as a way to protect against memory loss associated with Alzheimer's disease – a claim based on studies in mice. A recent study put this to the test in people. See the results in the "Niacin" section of the B Vitamin Supplements Review >>
Lower Cognitive Function in Kids Linked to High Prenatal Folic Acid
9/05/2017
Children of mothers who took high amounts of folic acid around the time of pregnancy had lower cognitive and verbal scores when tested at 4 to 5 years of age, according to a new study. Similarly, as we reported last year, pregnant women with higher levels of folate (from folic acid) had offspring with higher rates of autism. While it is important that pregnant women get a moderate amount of folic acid to prevent spinal cord defects, higher amounts should be avoided. See the Folate section of the B Vitamin Supplements Review for details.
High-Dose B Vitamins & Lung Cancer Risk
8/28/2017
A recent study found that taking high doses of vitamins B6 and B12 was associated with an increased risk of lung cancer among men, particulary among those who smoke. For details, see the "ConsumerTips" section of the B Vitamin Supplements Review >>
High-Dose B Vitamins & Cataract Risk
8/25/2017
Taking high doses of B vitamins, including B vitamin complexes, folic acid and B6, was associated with a higher risk of age-related cataracts among middle-aged men and women, according to a new study. For details, see the "ConsumerTips" section of the B Vitamin Supplements Review >>
How Vitamin B6 May Backfire
7/25/2017
Supplementing with high-dose vitamin B6 can sometimes cause the same nerve toxicity associated with deficiency of B6. New research explains why this may happen and suggests how to avoid it. For details, see the "Vitamin B6" section of the B Vitamin Supplements Review >>
Warning: Biotin Can Affect Thyroid Tests
6/19/2017
Vitamins that contain megadoses of biotin (vitamin B7) can affect thyroid tests, according to recent studies. This can lead to an incorrect diagnosis of hyperthyroidism and improper treatment. See the "Biotin" section of the B Vitamin Supplements Review >>
B12 Can Cause Acne
6/19/2017
Taking very large doses of vitamin B12 can cause outbreaks of acne -- even in older people, according to a recent report. Learn more in the "B12" section of the B Vitamin Supplements Review >>
Hip Fracture Risk With Too Much B-6
6/09/2017
A new study found that older men and women who took a high daily dose of vitamin B-6 had a 42% increased risk of hip fracture. Get the details in the "Vitamin B-6" section of the B Vitamin Supplements Review. Also, be aware that many supplements on the market contain the amount of B-6 used in this study, or more, in a daily serving! For help choosing a B-Complex or B-6 supplement that suits your needs without providing too much B-6, see our Top Picks among B vitamin supplements.
POTS and Thiamin
5/23/2017
A small study among people who suffer from POTS (postural tachycardia syndrome) suggested that supplementing with thiamin (vitamin B-1) may help some. For details, see the Thiamin (B-1) section of the B Vitamin Supplements Review >>
Niacin & Skin Cancer
4/18/2017
People who don't get enough niacin each day may be able to lower their risk of developing squamous cell skin cancer by getting a bit more niacin from their food or supplements suggests a recent analysis. However, this doesn't mean you should overdo it. For details, see the "Niacin" section of the B Vitamin Supplements Review. You can also find foods high in niacin using the food table in the report.
Cognitive Decline With Too Little B6
2/02/2017
A recent study among men and women in their 60's found that those getting inadequate amounts of vitamin B6 in their diets had much higher rates of cognitive decline. Get the details in the "What It Does" section of the B Vitamin Supplements Review (which includes our tests of products) >>
Side-Effect With B-12
1/19/2017
Certain formulations of vitamin B-12 contain additional ingredients that can cause diarrhea and bloating in some people — particularly if taking more than one pill. An apparent case of this was reported to us this week. To help you avoid this, read the details in the "What CL Found" section of the B Vitamin Supplements Review (which includes our tests of products) >>
Potential Risk with High B-12
1/09/2017
Among people who are malnourished, those with elevated vitamin B-12 levels in their blood were twice as likely to die when hospitalized as those with lower B-12 levels, according to a new study. The study authors suggest caution with inappropriate supplementation. For more details about the study, and vitamin B-12, see the B Vitamin Supplements Review >>
High-Dose Vitamin D Reduces Respiratory Infections, But With a Risk
1/09/2017
A study among older men and women found those who took high-dose vitamin D had fewer acute respiratory infections, but a greater number of falls. Get the details in the "What It Does" section of the Vitamin D Supplements Review >>
Too Much Folate & Nerve Damage
10/21/2016
One quarter of American men and women have a gene variation which puts them at higher risk of nerve damage if consuming too much of folate (vitamin B-9) daily, according to a new study. Considering that most older Americans consume more than this amount (largely due to excessive supplement use) this should be a warning to many. For more details, see the "Folate" section of the B Vitamins Review >>
Niagen Form of Niacin May Cause Flushing
10/10/2016
Niacin is known to cause flushing (redness) and skin tingling at moderate doses. Other forms of niacin are said cause less flushing. One of these is Niagen. However, results of a recently published study suggest that it can cause flushing and "hotness" after just a single dose. More details are in the "Niacin" section of the B Vitamin Supplements Review >>
Getting Too Much Folic Acid
9/15/2016
Researchers recently warned that many people who use supplements may be over-consuming synthetic forms of folate, which carries risks. Current labels are misleading. Get the details in the Folate section of the B Vitamins Review >>
Biotin Caution
8/19/2016
Very high-doses of biotin (vitamin B-7) can cause misleading laboratory results and lead to unnecessary antithyroid treatment, according to a new report. For details, see the Biotin section of the B Vitamins Supplements Review >>
Folic Acid Supplementation Mitigates Alzheimer's
7/04/2016
A recent study in people with Alzheimer's disease found that folic acid supplementation decreased inflammation and slightly improved mental functioning. However, participants began the study unusually low in folic acid relative to normal U.S. levels. For more details see the B Vitamin Supplements Review >> Also see results of a folate/B-12 study which showed reduced brain shrinkage in Alzheimer's patients.
B Vitamins & Autism Risk
6/11/2016
Excessive blood levels of B-12 and/or folate in pregnant women were found to be associated with an increased risk of autism in their children, according to a new study. While these vitamins are critical, too much may be problematic. Get the details in the B-12 and Folate sections of the B Vitamin Supplements Review >>
Omega-3's May Be Important in Preventing Cognitive Decline
1/19/2016
We have reported in the past that a certain combination of B vitamins slowed cognitive decline as well as brain shrinkage in older people. Now, further analyses finds that these benefits only occurred in people having certain blood levels of omega-3 fatty acids (as found in fish oil). Get the details in the B Vitamins Supplements Review >>
Niacin Helps Prevent Skin Cancers
10/23/2015
A study published this week showed that taking a form of niacin daily significantly lowered the rate of new basal-cell and squamous-cell skin cancers in patients with a history of such cancers. For details about the supplement and dose, see the B Vitamins Review >>
How Vitamin B-12 Causes Acne
6/26/2015
Vitamin B-12 is a critical nutrient and many people, particularly those over 50, should supplement with B-12 to avoid deficiency. However, at doses higher than those used to prevent deficiency, B-12 may occasionally trigger acne. A new study appears to explain the B-12/acne connection. For details, see the "Cobalamin (B-12)" section of the B Vitamin Supplements Review >>
Niacin Reduces Skin Cancer
5/15/2015
A recent study suggests that high-dose niacin (vitamin B-3) may reduce the risk of developing certain types of skin cancer. A closer look at the study, however, raises questions about its relevance to people in North America. Get the details, as well as more information about niacin and our product test results & comparisons, in the B Vitamin Supplements Review >>
Folic Acid Reduces Risk of Stroke
3/14/2015
A large study in people taking blood pressure-lowering medication found that the addition of a daily folic acid (vitamin B-9 or folate) supplement significantly reduced the chance of having a stroke. This benefit is most likely to occur among people whose blood levels of folate are low. More details, including dosage and ConsumerLab.com's test-based quality ratings of folic acid supplements, are found in the B Vitamin Supplements Review >>
Keep Energy Drinks Away from Kids
11/16/2014
It was reported this week that 40% of calls to poison centers for "energy drink exposure" involved children under age 6, many of whom experienced serious side effects. For more about this and other concerns with energy drinks, as well as our test results for popular products, see the B Vitamins & Energy Drinks Review >>
Do B Vitamins Boost Memory?
11/15/2014
This week, a study was reported in the media suggesting that taking vitamin B-12 and folic acid does not help with memory. But a closer look at this and related studies shows a benefit for some people. Get the details, plus our tests and comparisons of B-vitamin supplements, in the B Vitamin Supplements Review >>
Energy Drinks: Athletic Performance & Side Effects
10/07/2014
A recent study found that a caffeinated energy drink improved athletes' self-perceived muscle power, but also increased insomnia and nervousness. Get the details in the update to the B Vitamin Supplements and Energy Drinks Review >>
High-Dose Niacin with Statins Not Worth It
7/18/2014
Further evidence was published this week showing that the addition of high-dose niacin (vitamin B-3) to cholesterol-lowering treatment with statin drugs provides no worthwhile benefit and appears to increase the risk of adverse side events. For details, see the Review of B Vitamin Supplements and Energy Drinks >>
B-12 Deficiency and Acid Inhibitors
12/13/2013
A large, new study found the risk of vitamin B-12 deficiency to be significantly higher among people taking proton pump inhibitors (e.g., Prevacid, Prilosec) or H2-blockers (e.g., Pepcid, Zantac) than among those not taking these medications. The drugs reduce acid production in the stomach, but acid is needed to release B-12 from foods, so deficiency can occur. B-12 supplements can help because acid is not needed for their absorption. For details -- and our reviews of supplements with vitamin B-12 -- see the updated B Vitamin Supplements Review,
For more information, see ConsumerLab's answer to the question, I take omeprazole (Prilosec), a proton pump inhibitor, to reduce stomach acid. Are there supplements I should avoid, or be taking, due to this drug?.
B Vitamin Supplements for Stroke?
9/20/2013
A review of 14 clinical studies suggests that B vitamins may help prevent stroke. However, a deep reading of the report shows the benefit to be slight, at best. For details about the study, other uses of B vitamins (including B6, B-12, folic acid, niacin and complexes), and tests of these supplements, see the B Vitamin Supplements Review>>
Alzheimer's Changes Slowed with B Vitamins
5/26/2013
A combination of B vitamins was found to slow brain loss in areas of the brain associated with Alzheimer's disease. This same combination of vitamins has also been shown to slow cognitive decline. Get the details on who may (or may not) benefit, dosage, plus test results for over 35 B vitamin supplements in the updated B Vitamin Supplements Product Review >>
Concern Over Carnitine Causing Cardiovascular Disease
4/13/2013
Intake of L-carnitine from supplements (and from red meat) may foster atherosclerosis (hardening of the arteries), according to new research. Once ingested, L-carnitine is converted in some people to a compound which reduces the normal clearing of cholesterol from arteries.
For more details, see the updated reviews of B Vitamin Supplements & Energy Drinks and Protein Powders, as some of these products contain L-carnitine. The Acetyl-L-Carnitine Supplements review has also been updated because acetyl-L-carnitine is chemically similar to L-carnitine, suggesting a potential concern.
For more details, see the updated reviews of B Vitamin Supplements & Energy Drinks and Protein Powders, as some of these products contain L-carnitine. The Acetyl-L-Carnitine Supplements review has also been updated because acetyl-L-carnitine is chemically similar to L-carnitine, suggesting a potential concern.
Concern Over Niacin
3/16/2013
You may have heard that a recent study suggests that supplementing with niacin at high doses does more harm than good. This appears to be true in only certain situations. Get the facts in the update to the B Vitamin Supplements Review >>
Autism and Folic Acid Supplements
2/16/2013
A new study found that women who took folic acid supplements around the time of conception had a significantly reduced risk of bearing a child with autistic disorder. Get more details in the recent update to the folic acid section of the B Vitamins Review >>
Higher Vitamin Level May Slow Cognitive Decline
12/15/2012
An 8-year study of people in their 70's found that cognitive functioning (memory and other mental skills) declined faster among those with lower blood levels of vitamin B-12 compared to those with higher levels. Particularly surprising was that 40% of the people in the study fell into the lower B-12 group, many of whom had levels which would not normally define them as deficient in B-12. This and other recent studies suggest a role for vitamin B-12 in minimizing cognitive decline in older people. For details, see the updated B Vitamin Supplements Review. More >>
Caution with Energy Drinks
11/17/2012
The FDA has released reports showing deaths and other serious adverse events associated with the use of energy drinks like 5-hour Energy. As ConsumerLab.com reported in September, these small "shot" drinks can pack more caffeine than 2 cups of regular coffee. While the caffeine can keep you alert, there are a number of concerns to bear in mind and suggestions on how to more safely use these drinks. Learn more in the update to our B Vitamins and Energy Drinks Review. More >>
B Vitamin May Lower Blood Pressure
5/19/2012
According to a new study, approximately 10% of the population is genetically prone to high blood pressure which may respond dramatically to a low dose of riboflavin (vitamin B-2). Read the update to the B Vitamin Supplements Review for details, including the dose used and amount of blood pressure reduction achieved. More >>
B-12 and Folic Acid for Memory
1/07/2012
Small but significant improvements in short and long-term memory were found to occur in older people (aged 60 to 74) given modest daily amounts of vitamin B-12 and folic acid. But don't expect immediate results. Improvements were seen only after 2 years of supplementation. See the update in the B Vitamins Review for the dosage used, as well as our ratings of supplements with vitamin B-12 and folic acid.
No Benefit of Niacin with Statins
11/19/2011
According to a recently published study, high dose niacin added to statin drug treatment does not further reduce the risk of heart attacks and stroke despite improvements in levels of HDL cholesterol and triglycerides. In fact, there was a small increase in strokes among those taking niacin. However, a role remains for high dose niacin in lipid treatment. For details, see the update to the B Vitamin Supplements Review.
B Vitamins May Help Memory
10/29/2011
A recently published study of individuals aged 70 years or more with mild cognitive impairment found that a daily dose of three B vitamins (folic acid, vitamin B-12, and vitamin B-6) over 2 years appeared to slow cognitive and clinical decline, particularly in those who started with elevated levels of plasma homocysteine. See the B Vitamin Product Review for details including the dosage used. More >>
Niacin Concern Stops Cardiovascular Study
5/30/2011
A clinical trial using high dose niacin (vitamin B3) was recently stopped by the National Institutes of Health due to lack of benefit and a small increase in strokes. Patients in the study had cardiovascular disease and were already taking a statin drug to keep LDL ("bad") cholesterol levels low. The addition of high dose niacin was intended to increase HDL ("good") cholesterol, reduce elevated triglycerides, and, most importantly, reduce the risk of heart attacks and stoke. For more information, including the amount and type of niacin used in the study and additional information about niacin and niacin supplements, see the B Vitamin Supplements Review. More >>
Does folic acid affect the risk of colon cancer?
5/08/2011
Supplementation with higher amounts of folic acid (vitamin B-9) has been shown to increase the risk of prostate cancer, but its effect on the risk of colon cancer has been unclear. A new study found no increase in colon cancer due to folic acid supplementation. But if you supplement with folic acid, be careful. See the B Vitamin Supplements Review for more >>
